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Both intracerebral hemorrhage and ischemic stroke continue to be the leading causes of disability and the second leading causes of death worldwide.1,2 The burden is largest in low- and middle-income countries, which have seen rapid recent population growth. Large vessel occlusion (LVO – internal carotids, vertebrals and the proximal branches of the circle of Willis) accounts for 20% of all acute ischemic strokes (AISs) […]

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12 Results Found for “external trigeminal nerve stimulation”

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X-ray style image of human head and upper torso, highlighting brain in red, person holding head, suggesting headache or brain pain, medical concept
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In this narrative review, we aim to introduce the reader to the history of calcitonin gene-related peptide (CGRP) discovery and its involvement in migraine pathophysiology. We will then look at drug development and clinical trials in migraine. We will additionally ...

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Isabella Henderson, Nisali A Gunawardane, Ruben I Kuzniecky

Epilepsy affects approximately 1% of the global population, with one-third of patients remaining refractory to medical therapy.1 Drug-resistant epilepsy (DRE), defined as the failure of two appropriately chosen antiseizure medications (ASMs) to achieve seizure freedom, poses significant risks, including injury and ...

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Risako Shirane, Eonjung Kim, Daniela Riveros

Neuromodulation is a recent technique that has increasingly been used for the abortive and preventive treatment of migraine and other primary headache disorders.1 It has previously been found to be helpful in the treatment of other neurological illnesses, such as ...

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Welcome to the latest edition of touchREVIEWS in Neurology, which features a diverse range of topical articles covering therapeutic areas relevant to neurologists and other practitioners involved in the care of patients with neurological illness. We begin with an editorial ...

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Migraine is a common and disabling condition with substantial health and socioeconomic implications. Approximately 1.04 billion people worldwide have migraine disease.1 The condition disproportionately affects women, with 19% of women versus 10% of men reporting a history of migraine.1 Migraine is the second ...

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María Dolores Villar-Martinez, Peter J Goadsby

It cannot be seen, cannot be felt, cannot be heard, cannot be smelt. It lies behind stars and under hills, and empty holes it fills. It comes first and follows after, ends life, kills laughter. The Hobbit. JRR Tolkien ‘Darkness’ ...

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Migraine is the sixth most common form of disability globally that affects young, otherwise healthy subjects at the peak of their productive years.1 The management of chronic or refractory migraine with traditional pharmacological approaches can often prove challenging and unsatisfactory. ...

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The last major breakthrough in the treatment of migraine and cluster headache (CH) began in the 1980s with the development of subcutaneous sumatriptan, which was introduced to the US market in 1993. Sumatriptan was life-changing for many individuals with migraine, and ...

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Headache is the most common somatic complaint seen in the emergency department, accounting for 1 % to 3 % of all emergency department visits.1 Given the range of headache-related disorders, a systematic approach to headache classification and diagnosis is essential for best clinical management.2 ...

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Peripheral nerve stimulation (PNS) is a unique neuromodulation modality that is rapidly gaining popularity for a variety of clinical conditions. Despite its straightforward nature, the modality has been for a long time treated as a ‘stepchild’ of the neuromodulation field, ...

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Historical Perspective Historical Perspective The analgesic effect of electricity has been exploited for thousands of years (electric fish, static electricity) but it has been controllable only since the introduction of the Leyden jar in 1745. Electro-acupuncture was introduced in 1823. Peripheral nerve ...

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Migraine Diagnosis In a landmark study2 in adults, patients with a chief complaint of migraine had a final diagnosis of migraine. Patients with a chief complaint of sinus headache had a diagnosis of migraine, and patients with a chief complaint ...

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