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Both intracerebral hemorrhage and ischemic stroke continue to be the leading causes of disability and the second leading causes of death worldwide.1,2 The burden is largest in low- and middle-income countries, which have seen rapid recent population growth. Large vessel occlusion (LVO – internal carotids, vertebrals and the proximal branches of the circle of Willis) accounts for 20% of all acute ischemic strokes (AISs) […]

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Huntingtons disease cell structure abnormal protein buildup illustration neurodegenerative genetic disorder visualization
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Gloria Ibis Tirado Romero, Ana María Jiménez Echavarría, Laura Rocío Orrego-Agudelo

Huntington’s disease (HD) is a fatal, autosomal-dominant, neurodegenerative disorder caused by a cytosine–adenine–guanine (CAG) trinucleotide repeat expansion in the huntingtin (HTT) gene, located on chromosome 4p16.3. When this repeat exceeds 36 units, it leads to the synthesis of ...

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  There has been an explosion of data in the field of Alzheimer’s disease (AD), not only from clinical studies but also studies that generate hypotheses and opportunities that may accelerate drug development. In order to make optimal use ...

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Alzheimer’s disease (AD) is a multifactorial and heterogeneous disease in both its clinical and histopathological appearance. In more than 99% of cases the cause of the disease is not understood. Independent of its cause, AD is clinically characterised by a ...

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