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Both intracerebral hemorrhage and ischemic stroke continue to be the leading causes of disability and the second leading causes of death worldwide.1,2 The burden is largest in low- and middle-income countries, which have seen rapid recent population growth. Large vessel occlusion (LVO – internal carotids, vertebrals and the proximal branches of the circle of Willis) accounts for 20% of all acute ischemic strokes (AISs) […]

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The Alzheimer’s and Parkinson’s Diseases Conference (AD/PD) 2026, held in Copenhagen, Denmark, brought together over 5,800 delegates to discuss advances across neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and related disorders. ...

Huntingtons disease cell structure abnormal protein buildup illustration neurodegenerative genetic disorder visualization
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Gloria Ibis Tirado Romero, Ana María Jiménez Echavarría, Laura Rocío Orrego-Agudelo

Huntington’s disease (HD) is a fatal, autosomal-dominant, neurodegenerative disorder caused by a cytosine–adenine–guanine (CAG) trinucleotide repeat expansion in the huntingtin (HTT) gene, located on chromosome 4p16.3. When this repeat exceeds 36 units, it leads to the synthesis of ...

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The coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented illness and death among the global population. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can range from mild upper respiratory symptoms that subside with no lasting effects to multiorgan system failure ...

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  There has been an explosion of data in the field of Alzheimer’s disease (AD), not only from clinical studies but also studies that generate hypotheses and opportunities that may accelerate drug development. In order to make optimal use ...

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Vitamin D is an essential nutrient for bone homeostasis that has also been implicated in numerous other disorders, such as cardiovascular disease (CVD) and autoimmune diseases. Originally vitamin D deficiency was associated only with rickets and it was considered that ...

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Proceedings of the Meeting: Multiple Sclerosis Management – A Changing Landscape 2013, held on 26–27 April 2013 in Vienna, Austria Multiple Sclerosis Management 2013 The keynote lecture was given by Fred D Lublin (New York, New York, US), who outlined present and future challenges in ...

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Ischemic stroke remains the leading cause of adult disability in developed countries.1 Although clinical assessment is the key feature of patient management, additional tools such as biomarkers can be used to support a clinical diagnosis, identify patients at risk of ...

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Alzheimer’s disease (AD) is a multifactorial and heterogeneous disease in both its clinical and histopathological appearance. In more than 99% of cases the cause of the disease is not understood. Independent of its cause, AD is clinically characterised by a ...

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The monoamine hypothesis has dominated research into the pathophysiology and pharmacotherapy of depression for a long time. This has led to the development of antidepressants that are now more selective than the early tri- and tetracyclics from which they have ...

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