Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a ...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that displays heterogeneous age of onset, symptoms, and progression.1,2 The disease presents clinically with upper and lower motor neuron features.3 There is no definitive test or assay that can be used ...

Motor neuron disease (MND) encompasses a range of disorders that differentially affect the upper and lower motor neurons. Amyotrophic lateral sclerosis (ALS) is the most common form of MND. In ALS, both upper and lower motor neurons are affected.1 Amyotrophic ...

Myelopathy is a common diagnosis often made by clinical neurologists and can be a cause of significant disability. Differential diagnosis classically includes structural etiology, demyelinating, metabolic, nutritional, inherited, and degenerative causes, resulting in a vast array of pathophysiologic processes, underlying ...

Individuals with mutations in the superoxide dismutase 1 (SOD1) gene develop brain white matter abnormalities before the onset of symptoms of amyotrophic lateral sclerosis (ALS), according to a new imaging study that was presented here at the AAN Annual Meeting in ...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with selective and progressive loss of upper and lower motor neurons. Although this disease was identified more than 140 years ago by Charcot, the pathogenesis has yet remained unknown. Recent advancements in neuroimaging, ...

Amyotrophic lateral sclerosis (ALS) is characterised by progressive degeneration of upper (UMN) and lower (LMN) motor neurons in the brain and spinal cord. Rare in its own right, ALS is the most common form of motor neuron disease (MND). Primary ...

Alzheimer’s disease (AD) is the most common form of dementia and affects millions of people worldwide. The disorder is characterised by severe memory loss, with episodic memory being particularly impaired during the initial phases. Most AD cases occur sporadically, ...

Clinical Features of Amyotrophic Lateral Sclerosis Clinical Features of Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, is a neurological disorder characterized by the selective loss of upper and lower motor neurons in the brain and ...