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    An Introduction to Headache Disorders

    Headache disorders, most common debilitating disorders in the world, are responsible for almost three quarters of all neurological-related disabilities. Primary headache disorders include migraine, tension headache and cluster headache. The most common type of secondary headache is medication-overuse headache. The past decade has seen substantial breakthroughs in headache management. New therapeutic strategies target the CGRP ligand or receptor, transforming the treatment paradigm for migraine, and proving useful against cluster headache. Another novel strategy are ditans, a new class of acute treatments that target the serotonin 5-HT1F receptor.

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