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  • Neuromyelitis Optica Spectrum Disorder

    An Introduction to Neuromyelitis Optica Spectrum Disorder

    Neuromyelitis Optica Spectrum Disorder (NMOSD) an inflammatory disorder of the central nervous system encompassing brain syndrome as well as optic neuritis and acute myelitis. It is characterised by recurrent exacerbations and incomplete remissions, leading to accumulating disability. The discovery of antibodies against aquaporin 4 (AQP4) and their role in the pathophysiology of NMOSD has facilitated its differential diagnosis from multiple sclerosis, and led to therapeutic advances in seropositive individuals. However, many challenges remain. Approved targeted therapies, including monoclonal antibodies, can be expensive, leaving limited options for seronegative patients.

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