Data from the REFORM trial (NCT04674020) provide valuable insights into cortical inflammation in adults with migraines, using a novel quantitative, multimodal MRI technique to compare these patients with age- and gender-matched healthy controls, enhancing our understanding of migraine biology and other headache disorders. The discussion also covers cluster headaches, focusing on a study that examines premonitory symptoms in affected individuals and highlights key phenotypic characteristics. Additionally, we explore findings from the European Migraine & Headache Alliance on the stigma surrounding migraines, which yield insightful and actionable results. Looking ahead, the focus shifts to the latest data on new medications for preventing and treating migraine attacks, discussing future prospects and identifying areas in headache disorder management that still need further attention.

Explore ground-breaking advancements in the treatment of movement disorders in this insightful interview with Prof. K. Ray Chaudhuri, who shares his key takeaways from the 10th Congress of the European Academy of Neurology meeting in Helsinki. He discusses promising new therapies, personalized care approaches, and significant research on the staging of Parkinson's. Additionally, Prof. Chaudhuri emphasizes the importance of holistic treatment, stepped-care strategies, remote management, and the potential of wearable technology in improving patient outcomes, bringing his wealth of knowledge and insights to touchNEUROLOGY

Myasthenia gravis (MG) is an autoimmune disorder where antibodies disrupt the neuromuscular junction, causing muscle weakness that worsens with activity. MG subgroups are based on muscle weakness location, age, antibody type, and thymus pathology, with some patients experiencing severe, treatment-resistant symptoms. Biomarkers can indicate prognosis. First-line treatments include pyridostigmine for symptomatic relief and immunosuppressants like prednisolone and azathioprine. Thymectomy is recommended for certain patients. Second-line treatments include mycophenolate, rituximab, and others, with new therapies like complement and FcRn inhibitors showing promise. Intravenous immunoglobulin and plasma exchange are used for acute exacerbations. Supportive therapy, including adapted exercise, is crucial. In refractory cases, comorbidities and diagnosis accuracy should be reconsidered.

Key topics and highlights from the Late-Breaking News session at the European Academy of Neurology (EAN) meeting are discussed in this interview, where Dr. Miguel Miranda provides valuable insights. He addresses unmet medical needs in dementia, aging, and movement disorders, drawing on his experience from Unidade Funcional de Neurologia, Hospital de Cascais Dr. José de Almeida, Cascais, Portugal, as he joins touchNEUROLOGY.