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Motor neuron synapses with muscle fiber via electrical impulse transmission and neurotransmitter release, forming neuromuscular junctions , motor neuron, neuroscience
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

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Broadest approval to date in generalized myasthenia gravis The FDA approval of nipocalimab for generalized myasthenia gravis (gMG) introduces a targeted therapy within a validated class, offering the potential for durable disease control across the broadest patient population to date. ...

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In this next Q&A we welcome Prof. Dr Murat Emre. Prof. Emre studied medicine in Istanbul University and specialized in neurology in Zurich University Hospital in Zurich, Switzerland. After his training he did fellowships in movement disorders in Queen Square Hospital London and in behavioural neurology in Beth Israel Hospital, Harvard Medical School in Boston, he also worked in clinical research to develop new drugs for Parkinson's disease and Azlheimer disease. Upon his return to Turkey he founded the Movement Disorders and behavioural Neurology Unit in the Department of Neurology, İstanbul Faculty of Medicine. His main areas of interest are Parkinson!'s disease, in particular cognitive aspects/dementia and Alzheimer disease.

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In our next expert Q&A we are delighted to welcome Dr Stewart Tepper. Dr Tepper, is a distinguished figure in the field of Neurology, currently serving as the Vice President of the New England Institute for Neurology and Headache (NEINH) in Stamford, Connecticut, and as a Professor of Neurology at the Geisel School of Medicine at Dartmouth.

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In a new consensus statement, the American Headache Society recommends CGRP-targeting therapies as first-line options for migraine prevention, alongside existing treatments, without necessitating prior failure of other preventive treatments.

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Welcome to the latest edition of touchREVIEWS in Neurology. We are excited to present a collection of articles that showcase the latest advancements and diverse perspectives in neurological research and treatment. This issue features insightful reviews and editorials from esteemed ...

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Patrick Schindler, Friedemann Paul

Neuromyelitis optica spectrum disorders (NMOSD) are a group of relapsing autoimmune diseases of the central nervous system. The clinical hallmarks of NMOSD are myelitis and optic neuritis; however, a wider clinical spectrum has been recognized.1 The majority of patients with ...

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Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory autoimmune disease of the central nervous system (CNS) with a worldwide distribution.1 The first clinical description of NMOSD was made a century ago by Devic and Gault, who documented patients with ...

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Over the past two decades, monoclonal antibodies targeting the surface antigen CD20 have emerged as highly effective disease-modifying therapies (DMTs) for multiple sclerosis (MS).1 The major mechanism of action of these therapies is via B-cell depletion, as CD20 is expressed ...

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Myasthenia gravis (MG) represents the major and most frequent primary disorder of the neuromuscular junction. Clinical hallmarks are variable and include exercise-induced weakness involving extraocular, bulbar, limb and/or axial muscles.1 Respiratory involvement, characterized by orthopnoea or dyspnoea with exertion, ...

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Oki Ishikawa, Stella Hahn, Harly Greenberg

Narcolepsy is a chronic clinical condition primarily characterized by excessive daytime sleepiness (EDS). This may be accompanied by cataplexy, which is a phenomenon of transient muscle weakness triggered by strong emotions, such as laughter, excitement, anger or grief. Narcolepsy is ...

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Saša A Živkovic‘, Tawfiq Al-Lahham

The clinical use of cancer immunotherapy with immune checkpoint inhibitors (ICI) has transformed cancer management and added another effective treatment option for different types of malignancies.1–3 In 2018, the Nobel Prize for medicine and physiology was awarded for the discovery of ...

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Saranya B Gomathy, Ayush Agarwal, Venugopalan Y Vishnu

Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies against the myoneural junction, which lead to impaired neuromuscular transmission. These antibodies act at the post-synaptic membrane, commonly against the nicotinic acetylcholine receptor (AChR) but in some cases, antibodies to ...

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