Alzheimer's Disease & Dementia
An Introduction to Alzheimer's Disease & Dementia
Major advances in the understanding of the pathogenesis of Alzheimer’s disease (AD), the most common form of dementia, have occurred over recent years, but the need for truly disease-modifying therapies remains. Novel pharmacotherapy strategies under investigation include the repurposing of medications used to treat non-AD illnesses and multi-target-directed ligands, offering promise in this challenging treatment landscape.
Browse video highlights and short articles from the conference hub, providing insights into the latest updates from major conferences and peer-reviewed articles from our journal touchREVIEWS in Neurology. This is complimented by a range of educational activities developed in collaboration with our leading expert faculty.
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Alzheimer's Disease & Dementia Content
Kristen George, AAIC 2022: Experiences of discrimination on cognitive function and ageing among the oldest old: The LifeAfter90 (LA90) Study
The LifeAfter90 (LA90) Study aims to understand what cognitive ageing and dementia look like among individuals aged 90 and above. In this interview, Dr Kristen George (University of California Davis School of Medicine, University of California, Davis, CA, USA) discussed what the study found in terms of the effect of discrimination on the cognitive function of this […]
Claire Sexton: Highlights of AAIC 2022
The Alzheimer’s Association International Conference (AAIC) is the largest and most influential meeting dedicated to advancing Alzheimer’s and dementia research. Each year, it gathers researchers to share discoveries that’ll lead to methods of prevention and treatment and improvements in the diagnosis of Alzheimer’s disease. Dr Claire Sexton is the senior director of Scientific Programs […]
Dr Jennifer Bute: Living with dementia – the importance of laughter and hope
Dr Jennifer Bute is a retired GP living with dementia. She shares her experiences of diagnosis and describes the strategies that are helpful for her. Jennifer also highlights the importance of laughter, engagement and hope. Touch Medical Media is sharing educational resources on World Brain Day (22 July 2022) to help achieve brain health for […]
Elisabeth Hendrickx Van de Craen, EAN 2022: Rare ABCA7 mutations and Alzheimer’s disease
ABCA7 is a major risk gene for Alzheimer’s disease (AD), and rare premature termination codon and missense mutations are enriched in AD patients. Elisabeth Hendrickx Van de Craen (VIB-UAntwerpen, University of Antwerp, Antwerp, Belgium) spoke with touchNEUROLOGY about the findings of her study with patients presenting with cerebral amyloid angiopathy and Alzheimer’s disease, and how […]
Oliver Cousins, EAN 2022: Effect of TREM2 on neurodegenerative diagnosis
The effect of TREM2 on neurodegenerative diagnosis, cognitive profile and brain structure are discussed in this touchNEUROLOGY interview with Dr Oliver Cousins (King’s College London, London, UK). Microglial genes are risk factors for neurodegenerative disease. This study investigated the association between different TREM2 variants and neurodegenerative disease and evaluated their association with brain structure and […]
Emerging Perspectives in the Management of Agitation in Alzheimer’s Disease and Patients with Dementia
touchREVIEWS in Neurology. 2022;18(1):7–13 DOI: https://doi.org/10.17925/USN.2022.18.1.7
While Alzheimer’s disease (AD), the most common cause of dementia, is perhaps best characterized by cognitive decline, more than 90% of patients with dementia exhibit behavioural and psychological symptoms of dementia.1 The Cache County Study on Memory in Aging describes six areas of neuropsychiatric behavioural abnormalities in patients with AD and other dementias, comprising aggression, apathy, […]
Sharon Cohen, AD/PD 2022: Achieving timely, accurate, neuropathological diagnosis and precision management in early Alzheimer’s disease
Dr Sharon Cohen joins touchNEUROLOGY to discuss the challenges in diagnosing Alzheimer’s disease (AD) at an early stage, the most exciting recent developments in diagnostic criteria, genetic testing, and neuroimaging techniques. Dr Cohen also talks through the recent developments in biomarker strategies for diagnosis and precision management of early AD. The presentation entitled: ‘Accelerating Progress […]
Sharon Cohen, AAN 2022: Long-term safety and efficacy of aducanumab in Alzheimer’s disease – Baseline EMBARK data from EMERGE, ENGAGE, and PRIME
Aducanumab is a human monoclonal antibody targeting soluble and insoluble amyloid beta (Aβ) aggregates. Aducanumab was approved in June 2021 for the treatment of mild cognitive impairment due to Alzheimer’s disease or mild dementia due to Alzheimer’s disease by the FDA under the accelerated approval pathway. Dr Sharon Cohen (Toronto Memory Program, Toronto, Canada) discusses […]
Tim Bartels: Highlights at AD/PD 2022
Dr Tim Bartels (UK Dementia Research Institute, University College London, London, UK) joins touchNEUROLOGY to discuss the highlights from this year’s AD/PD 2022 conference. He discusses some of his personal highlights in the field of new therapeutics for neurodegeneration, and also the presentation of functioning MRI agents for α-Synuclein. Question: What are some of the […]
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