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A digital rendering of a human brain with highlighted neural pathways and electric activity, visualizing brain function.
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Pavel Burko, Ilias Miltiadis, Mahsa Alavi

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

A multi-chamber device for studying neural degeneration

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Published Online: May 4th 2014

NC3Rs-funded researchers, Professor Hugh Perry and Dr Tracey Newman, University of Southampton, have developed a microfluidic device that creates a suitable environment to study what happens during neuronal injury. This better understanding can inform how drugs are tested at the later stages of development, reducing the number of rodents that would be required.

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