An Introduction to Parkinson's Disease
Parkinson’s disease (PD), the most common movement disorder, is characterized by dopamine deficiency and motor symptoms, such as tremor, rigidity, bradykinesia and impaired balance; non-motor symptoms are increasingly being recognized as important too. Despite advances in our understanding of PD by functional genetics, brain imaging and biomarker detection, it remains incurable. While levodopa remains the mainstay of therapy, other treatments include levodopa plus carbidopa (oral/gel infusion), dopamine agonists, MAO-B and COMT inhibitors, anticholinergics and amantadine. Latest approvals include opicapone, a COMT inhibitor, and istradefylline, an adenosine A2A antagonist; both boost the effect of levodopa for better symptom control. Investigational approaches include disease-modifying therapies targeting α-synuclein and its pathways, immunotherapies, stem-cell therapy and non-pharmacological interventions targeting motor symptoms, including gene therapy and adaptive deep-brain stimulation.
Browse video highlights and short articles from the conference hub, providing insights into the latest updates from major conferences and peer-reviewed articles from the journal portfolio. This is complimented by a range of educational activities from our expert faculty, with patient outcomes at the forefront.
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Parkinson's Disease Content
New Levodopa Infusion Systems for Advanced Parkinson’s Disease
touchREVIEWS in Neurology. 2024;20(1):Online ahead of journal publication
Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder characterized by the degeneration of nigrostriatal dopaminergic neurons, with its incidence increasing globally.1 With disease progression, the benefit from medications shortens, and symptom control becomes strictly dependent on peripheral levodopa (L-dopa) levels, leading to the development of daily fluctuations of motor and non-motor symptoms severity and L-dopa-induced […]
Angelo Antonini, EAN 2023: Highlights in Parkinson’s disease
touchNEUROLOGY editorial board member Prof. Angelo Antonini (Padua University Hospital, Italy) provides an overview of his top three most important updates and hot topics from the annual European Academy of Neurology (EAN), July 1–4, 2023, in the field of Parkinson’s disease. He particularly focusses on new insights in early detection of the disease before motor symptoms […]
Highlights from EAN 2023!
Wellness in Parkinson’s Disease: A Framework for Management Using a Holistic Culturally Sensitive Approach
touchREVIEWS in Neurology. 2023;19(1):8–13 DOI: https://doi.org/10.17925/USN.2023.19.1.8
In modern medicine, the concept of wellness is accompanied by many misconceptions. Adopting wellness as a treatment approach has been well defined and implemented in cardiovascular disease, diabetes and some types of cancer management but has not yet been widely applied to neurologic diseases.1–5 The commercialization of the wellness industry has led to the misconception of wellness as expensive and only accessible to a niche population […]
The place of on-demand therapy in the treatment of OFF episodes
Learn about the treatment paradigm for OFF and the place of on-demand therapy in it.
The impact of delayed ON: Treating OFF episodes in patients with Parkinson’s disease
Leading experts Stuart Isaacson MD, Yasar Torres-Yaghi MD, Rajesh Pahwa MD discuss how to reduce the impact of delayed ON in Parkinson’s disease
Veronica Clark, Parkinson’s Europe: Presidential Update, and the Parkinson’s Manifesto for Europe
The European Parkinson’s Disease Association (EPDA) recently changed its name to Parkinson’s Europe. They are the only European Parkinson’s umbrella organisation and have been working with the global Parkinson’s community for nearly 30 years. As a leading voice for Parkinson’s in Europe, they provide trusted information; advance and share good practices; raise awareness and improve […]
Suman Kushwaha, MDS 2022: COVID-19 vaccine induced parkinsonism and cognitive dysfunction
Two cases of COVID-19 vaccination associated neurological symptoms were presented, with patients displaying parkinsonism and cognitive dysfunction. In this touchNEUROLOGY interview, we speak with Dr Suman Kushwaha (Institute of Human Behaviour and Allied Sciences (IHBAS), Dilshad Garden, Delhi, India) to discuss the neurological symptoms and investigations leading to the case report conclusions. The abstract entitled […]
Suman Kushwaha, MDS 2022: Neurological symptoms and COVID-19 vaccination
Neurological complications, such as peripheral neuropathy, have been associated with COVID-19 vaccination. In this touchNEUROLOGY interview, we speak with Dr Suman Kushwaha (Institute of Human Behavior and Allied Sciences (IHBAS), Dilshad Garden, Delhi, India) to discuss the neurological symptoms that have been observed. The abstract entitled ‘Covid vaccine induced parkinsonism and cognitive dysfunction’ was presented […]