An Introduction to Neuropathic Pain
Neuropathic pain is the result of an injury or illness that impacts the somatosensory system, responsible for the perception of touch, pain, pressure etc. arising from inside and the surface of the body. Common causes include amputation, chemotherapy, diabetes, multiple sclerosis and shingles. The multifactorial nature of the condition makes neuropathic pain challenging to diagnose and treat. Combination therapy is commonplace. Despite this, a high proportion of still patients fail to achieve adequate pain relief with manageable side effects. Multidisciplinary care is essential and includes nonopioid pharmacological management, interventional therapies, neurostimulation, low-dose opioid treatment and targeted drug-delivery therapy.
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Neuropathic Pain Content
Radial Neuropathy Following Surgical Procedures Conducted Under General Anesthesia —A Single-center Cross-sectional Study
US Neurology. 2020;16(1):61–5 DOI: https://doi.org/10.17925/USN.2020.16.1.61
Proper intraoperative positioning is a simple, yet crucial, component of a successful operation. During each surgical procedure, a position should be employed, which not only meets the surgeon’s requirements, but also has the fewest disadvantages for the patient. Peripheral neuropathies, such as those affecting the ulnar nerve, brachial plexus, lumbosacral roots, and radial nerve are […]
Raili Kauppinen, EAN 2020 – ENVISION Study in Patients With Acute Hepatic Porphyria
Raili Kauppinen (University Hospital of Helsinki, Finland) shares key findings and insights into the ENVISION study, which evaluated the efficacy and safety of givosiran, a subcutaneously administered RNA interference therapeutic targeting aminolevulinic acid synthase 1, in patients with acute hepatic porphyrias (ClinicalTrials.gov Identifier: NCT03338816). Questions 1. Could you give us a brief overview of acute […]
Nadine Attal, EAN 2020 – Therapeutic Cannabis: Is It Really Helpful for Neuropathic Pain?
Nadine Attal (University Versailles Saint Quentin, Versailles, France) shared with us her expert opinion on the controversial topic of therapeutic cannabis for neuropathic pain. Questions 1. What advantages does cannabis offer compared to current pharmacological treatments for neuropathic pain? (0:05) 2. What can we conclude about the clinical evidence to date? (0:41) 3. What have […]
Hypervigilance in the Detection of Early Complex Regional Pain Syndrome, Type 1/Reflex Sympathetic Dystrophy—An Underutilized Tool in Treatment
US Neurology. 2020:16(1):43–9 DOI: https://doi.org/10.17925/USN.2020.16.1.43
Complex regional pain syndrome, type 1 (CRPS1)/reflex sympathetic dystrophy (RSD) is a neuropathic pain disorder,1 with pain reflecting partially damaged nerve fibers.2 It is normally caused by traumatic injury, further aggravated by neuroinflammation.3 The latter contributes to the devastating potential for CRPS1/RSD progressing to a permanent, totally disabling condition.4 Identifying CRPS early, when classical features […]
Herpes Zoster Radiculopathy in a Systemic Lupus Erythematosus Patient – A Case Report
European Neurological Review. 2018;13(2):116–9 DOI: https://doi.org/10.17925/ENR.2018.13.2.116
Herpes zoster, also known as shingles, is one of the many manifestations of neurologic disorders and occurs with a cumulative life-time incidence of 10–20% in the general population.1 The annual incidence of this disease differs worldwide; in the UK, herpes zoster is found in 0.37 per 1,000 population, with the risk of a second attack […]
Prevalence and Pattern of Craniofacial Pain and Headache in Danish Patients with Neuromyelitis Optica Spectrum Disorder
European Neurological Review. 2018;13(1):44–52 DOI: https://doi.org/10.17925/ENR.2018.13.1.44
Neuromyelitis optica spectrum disorder Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS) causing severe inflammation and demyelination of the optic nerve (optic neuritis [ON]), the spinal cord (transverse myelitis [TM]) and the brainstem.1,2 There is a dearth of epidemiological data on the prevalence of NMOSD; conclusive data […]
Association Between the ABO Blood Types and Post-operative Pain
European Neurological Review. 2018;13(1):38–43 DOI: https://doi.org/10.17925/ENR.2018.13.1.38
Acute pain is defined as an ‘unpleasant, complex, dynamic psychophysiological response to tissue damage, disease or inflammation’,1–3 and often lasts for a short period.1,4 Its biological function is to minimise behaviours that may lead to reduced tissue healing.1,5 When patients are recovering from a surgery, uncontrolled acute post-operative pain often occurs, which can be damaging.1 […]
Virtual Reality for Pain Control—Virtual or Real?
US Neurology, 2016;12(2):82–3 DOI: https://doi.org/10.17925/USN.2016.12.02.82
Chronic pain affects millions of people around the globe. Current consensus considers chronic pain as a disease that arises from maladaptive changes within the central nervous system. Chronic pain poses a huge impact on affected individuals, societies, and health care systems. Current available medications or other treatment strategies are still far from providing an optimal, […]
The Biopsychosocial Model of the Assessment, Prevention, and Treatment of Chronic Pain
US Neurology, 2016;12(2):98–104 DOI: https://doi.org/10.17925/USN.2016.12.02.98
Chronic pain is a widespread, debilitating condition shared by millions worldwide. In 2015, more than 25 million Americans reported suffering from consistent daily pain.1 The Center for Disease Control (CDC) reported 15.6% of American adults experience consistent headaches or migraines, 29% have consistent low back pain, and 14.9% suffer consistent neck pain. With pain conditions […]
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