An Introduction to Neuropathic Pain
Neuropathic pain is the result of an injury or illness that impacts the somatosensory system, responsible for the perception of touch, pain, pressure etc. arising from inside and the surface of the body. Common causes include amputation, chemotherapy, diabetes, multiple sclerosis and shingles. The multifactorial nature of the condition makes neuropathic pain challenging to diagnose and treat. Combination therapy is commonplace. Despite this, a high proportion of still patients fail to achieve adequate pain relief with manageable side effects. Multidisciplinary care is essential and includes nonopioid pharmacological management, interventional therapies, neurostimulation, low-dose opioid treatment and targeted drug-delivery therapy.
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Neuropathic Pain Content
Regional Techniques and Interventions for Intractable Neuropathic Pain
touchREVIEWS in Neurology. 2021;17(1): Online ahead of journal publication
Neuropathic pain arises from injury to or disease in the somatosensory nervous system.1 Normal sensation and pain sensation are both impaired and patients may present with peculiar painful characteristics such as allodynia and hyperalgesia.2 Central neuropathic pain includes pain from spinal cord injury and demyelinating diseases of the spinal cord, such as multiple sclerosis.1 Lesions or disease of […]
Erika Petersen, AAN 2021: Spinal Cord Stimulation Treatment of Painful Diabetic Neuropathy
We were delighted to speak with Prof. Erika Petersen (University of Arkansas for Medical Sciences, Little Rock, AR, USA) around the six month results from the SENZA-PDN study. The abstract entitled: ‘Sustained Benefits for 10 kHz Spinal Cord Stimulation Treatment of Painful Diabetic Neuropathy—Six Month Results from a Multicenter Randomized Controlled Trial’ was presented at […]
Radial Neuropathy Following Surgical Procedures Conducted Under General Anesthesia —A Single-center Cross-sectional Study
US Neurology. 2020;16(1):61–5 DOI: https://doi.org/10.17925/USN.2020.16.1.61
Proper intraoperative positioning is a simple, yet crucial, component of a successful operation. During each surgical procedure, a position should be employed, which not only meets the surgeon’s requirements, but also has the fewest disadvantages for the patient. Peripheral neuropathies, such as those affecting the ulnar nerve, brachial plexus, lumbosacral roots, and radial nerve are […]
Raili Kauppinen, EAN 2020 – ENVISION Study in Patients With Acute Hepatic Porphyria
Raili Kauppinen (University Hospital of Helsinki, Finland) shares key findings and insights into the ENVISION study, which evaluated the efficacy and safety of givosiran, a subcutaneously administered RNA interference therapeutic targeting aminolevulinic acid synthase 1, in patients with acute hepatic porphyrias (ClinicalTrials.gov Identifier: NCT03338816). Questions 1. Could you give us a brief overview of acute […]
Nadine Attal, EAN 2020 – Therapeutic Cannabis: Is It Really Helpful for Neuropathic Pain?
Nadine Attal (University Versailles Saint Quentin, Versailles, France) shared with us her expert opinion on the controversial topic of therapeutic cannabis for neuropathic pain. Questions 1. What advantages does cannabis offer compared to current pharmacological treatments for neuropathic pain? (0:05) 2. What can we conclude about the clinical evidence to date? (0:41) 3. What have […]
Hypervigilance in the Detection of Early Complex Regional Pain Syndrome, Type 1/Reflex Sympathetic Dystrophy—An Underutilized Tool in Treatment
US Neurology. 2020:16(1):43–9 DOI: https://doi.org/10.17925/USN.2020.16.1.43
Complex regional pain syndrome, type 1 (CRPS1)/reflex sympathetic dystrophy (RSD) is a neuropathic pain disorder,1 with pain reflecting partially damaged nerve fibers.2 It is normally caused by traumatic injury, further aggravated by neuroinflammation.3 The latter contributes to the devastating potential for CRPS1/RSD progressing to a permanent, totally disabling condition.4 Identifying CRPS early, when classical features […]
Herpes Zoster Radiculopathy in a Systemic Lupus Erythematosus Patient – A Case Report
European Neurological Review. 2018;13(2):116–9 DOI: https://doi.org/10.17925/ENR.2018.13.2.116
Herpes zoster, also known as shingles, is one of the many manifestations of neurologic disorders and occurs with a cumulative life-time incidence of 10–20% in the general population.1 The annual incidence of this disease differs worldwide; in the UK, herpes zoster is found in 0.37 per 1,000 population, with the risk of a second attack […]
Prevalence and Pattern of Craniofacial Pain and Headache in Danish Patients with Neuromyelitis Optica Spectrum Disorder
European Neurological Review. 2018;13(1):44–52 DOI: https://doi.org/10.17925/ENR.2018.13.1.44
Neuromyelitis optica spectrum disorder Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS) causing severe inflammation and demyelination of the optic nerve (optic neuritis [ON]), the spinal cord (transverse myelitis [TM]) and the brainstem.1,2 There is a dearth of epidemiological data on the prevalence of NMOSD; conclusive data […]
Association Between the ABO Blood Types and Post-operative Pain
European Neurological Review. 2018;13(1):38–43 DOI: https://doi.org/10.17925/ENR.2018.13.1.38
Acute pain is defined as an ‘unpleasant, complex, dynamic psychophysiological response to tissue damage, disease or inflammation’,1–3 and often lasts for a short period.1,4 Its biological function is to minimise behaviours that may lead to reduced tissue healing.1,5 When patients are recovering from a surgery, uncontrolled acute post-operative pain often occurs, which can be damaging.1 […]
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