An Introduction to Neuropathic Pain
Neuropathic pain is the result of an injury or illness that impacts the somatosensory system, responsible for the perception of touch, pain, pressure etc. arising from inside and the surface of the body. Common causes include amputation, chemotherapy, diabetes, multiple sclerosis and shingles. The multifactorial nature of the condition makes neuropathic pain challenging to diagnose and treat. Combination therapy is commonplace. Despite this, a high proportion of still patients fail to achieve adequate pain relief with manageable side effects. Multidisciplinary care is essential and includes nonopioid pharmacological management, interventional therapies, neurostimulation, low-dose opioid treatment and targeted drug-delivery therapy.
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Neuropathic Pain Content
Patients’ Beliefs in Optimal Pain Management: A Pilot Study
touchREVIEWS in Neurology. 2023;19(1):Online ahead of journal publication
Opioid therapy has become a mainstay for the treatment of chronic pain, despite evidence that these medications may be ineffective and even unsafe in this patient population.1,2 In patients with chronic back pain, the use of first-line medications (non-steroidal anti-inflammatory drugs and acetaminophen) declined by 48% from 1999 to 2010; simultaneously, there was a 53% rise […]
José A. López García, EAN 2021: Clinical Development of SAN711, and its Potential to Treat Neuropathic Pain
It was a pleasure to meet with José A. López García (University of Alcalá, Alcalá de Henares, Spain) to discuss the clinical development of SAN711, a selective GABAA α3 receptor positive allosteric modulator for the potential treatment of neuropathic pain. The abstract entitled: ‘SAN711 a selective GABAA α3 receptor positive allosteric modulator as a novel […]
Functional and Pain Improvement in Tennis Elbow with Dry Needling as Alternative Treatment: Case Series
touchREVIEWS in Neurology. 2021;17(1):60-3 DOI: https://doi.org/10.17925/USN.2021.17.1.60
Lateral epicondylitis, or tennis elbow, is pain in the lateral elbow as a result of repetitive forearm pronation and supination in elbow extension.1 It is a frequent cause of elbow pain, and affects 1–3% of the adult population every year, resulting in decreased productivity and economic losses.2,3 Equally present in males and females, it mostly occurs between […]
Regional Techniques and Interventions for Intractable Neuropathic Pain
touchREVIEWS in Neurology. 2021;17(1):16-22 DOI: https://doi.org/10.17925/USN.2021.17.1.16
Neuropathic pain arises from injury to or disease in the somatosensory nervous system.1 Normal sensation and pain sensation are both impaired and patients may present with peculiar painful characteristics such as allodynia and hyperalgesia.2 Central neuropathic pain includes pain from spinal cord injury and demyelinating diseases of the spinal cord, such as multiple sclerosis.1 Lesions or disease of […]
Erika Petersen, AAN 2021: Spinal Cord Stimulation Treatment of Painful Diabetic Neuropathy
We were delighted to speak with Prof. Erika Petersen (University of Arkansas for Medical Sciences, Little Rock, AR, USA) around the six month results from the SENZA-PDN study. The abstract entitled: ‘Sustained Benefits for 10 kHz Spinal Cord Stimulation Treatment of Painful Diabetic Neuropathy—Six Month Results from a Multicenter Randomized Controlled Trial’ was presented at […]
Radial Neuropathy Following Surgical Procedures Conducted Under General Anesthesia —A Single-center Cross-sectional Study
US Neurology. 2020;16(1):61–5 DOI: https://doi.org/10.17925/USN.2020.16.1.61
Proper intraoperative positioning is a simple, yet crucial, component of a successful operation. During each surgical procedure, a position should be employed, which not only meets the surgeon’s requirements, but also has the fewest disadvantages for the patient. Peripheral neuropathies, such as those affecting the ulnar nerve, brachial plexus, lumbosacral roots, and radial nerve are […]
Raili Kauppinen, EAN 2020 – ENVISION Study in Patients With Acute Hepatic Porphyria
Raili Kauppinen (University Hospital of Helsinki, Finland) shares key findings and insights into the ENVISION study, which evaluated the efficacy and safety of givosiran, a subcutaneously administered RNA interference therapeutic targeting aminolevulinic acid synthase 1, in patients with acute hepatic porphyrias (ClinicalTrials.gov Identifier: NCT03338816). Questions 1. Could you give us a brief overview of acute […]
Nadine Attal, EAN 2020 – Therapeutic Cannabis: Is It Really Helpful for Neuropathic Pain?
Nadine Attal (University Versailles Saint Quentin, Versailles, France) shared with us her expert opinion on the controversial topic of therapeutic cannabis for neuropathic pain. Questions 1. What advantages does cannabis offer compared to current pharmacological treatments for neuropathic pain? (0:05) 2. What can we conclude about the clinical evidence to date? (0:41) 3. What have […]
Investigating Factors Predictive of High Performance in a Multidisciplinary Pain Medicine Team
An expert interview with Robert Bolash, Departments of Pain Management and Evidence Based Pain Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA In this expert interview, Robert Bolash, an Assistant Professor of Anesthesiology in the Departments of Pain Management and Evidence Based Pain Research at the Cleveland Clinic Lerner College of Medicine, OH, […]
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