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Motor neuron synapses with muscle fiber via electrical impulse transmission and neurotransmitter release, forming neuromuscular junctions , motor neuron, neuroscience
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

Neuroimmunology

An Introduction to Neuroimmunology

Supported by:
EUROPEAN PARTNER
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Coverage from: EAN 2025
Marcello Moccia

At EAN 2025, Prof. Moccia shared his perspective on the evolving multiple sclerosis McDonald criteria, the role of advanced imaging and fluid biomarkers, and the exciting innovations reshaping MS diagnosis and management.

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Physician burnout is at a critical point. In this episode, Nicky speaks with Dr Alfred Atanda about why so many physicians are burning out and what can be done to change the trend. From personal experience to system-wide solutions, Dr Atanda shares valuable insights on improving physician well-being and building a more effective healthcare culture.

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What if your medical degree could launch more than a clinical career? In this candid and compelling read, Dr Jon Edelson shares his lessons for early-career clinicians ready to think beyond the bedside and explore the business of medicine.

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In this episode, we explore the future of continuing medical education (CME) with the team behind touchIME. Hannah Fisher and Matthew Goodwin share insights into global and US trends, the importance of patient inclusivity and how educational outcomes are evolving to better measure the direct impact of learning on clinical practice and patient care.

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 "this is a field where rigorous science can rapidly change lives"   Dr Bardia Nourbakhsh, Associate Professor of Neurology, Johns Hopkins University, Baltimore, MD, USA, is a rising star whose work bridges rigorous clinical neurological research with compassionate, patient-centred care. ...

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Multiple sclerosis (MS) is a chronic neurological condition that often presents with vague or intermittent symptoms, making early recognition particularly challenging in primary care. As diagnostic delays can significantly impact long-term outcomes, timely identification and referral are critical. In alignment ...

12 mins
CE/CME accredited
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touchEXPERT FOCUS
Prof. Xavier Montalban

Join an expert as they discuss MS pathophysiology and the potential of BTK inhibitors to delay progression.

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Brain Awareness Week, taking place from March 10-16, 2025, is a global campaign dedicated to fostering public enthusiasm and support for brain science, organised by the Dana Foundation. Each March, participants worldwide organize imaginative activities that highlight the wonders of the brain and the profound impact of neuroscience on our daily lives.

101 mins
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touchMEETING HIGHLIGHTS
For HCPs in: Global
This content is sponsored by Alexion, AstraZeneca Rare Disease.

Leading experts discuss clinical evidence and real-world experience with complement inhibition therapy in the rare autoimmune disorders AChR-Ab+ gMG and AQP4-Ab+ NMOSD.

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A new study has revealed that early treatment with ocrelizumab significantly reduces disease activity and long-term progression in patients with early-stage relapsing-remitting multiple sclerosis (RRMS).

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In this episode, we’re joined by Bradley Love, Professor of Cognitive and Decision Sciences at UCL, ELLIS fellow, and creator of BrainGPT. We discuss how this large language model is poised to assist researchers in advancing their work.

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In our latest Q&A, we are delighted to welcome Editorial Board member Dr David Hafler, William S. and Lois Stiles Edgerly Professor and Chairman of the Department of Neurology at Yale School of Medicine, as well as Neurologist-in-Chief at Yale-New Haven Hospital. Dr Hafler's groundbreaking work in multiple sclerosis (MS) research has helped establish the disease as an autoimmune disorder and led to the development of therapies such as natalizumab. His contributions include identifying myelin-reactive T cells, uncovering the genetic and molecular mechanisms underlying MS, and exploring the role of salt in driving autoimmune responses. A highly cited neurologist, he has received numerous awards, including the Dystel Prize, the Raymond Adams Award, and the NIH Javits Investigator Award, and is a member of the National Academy of Medicine.

Coverage from: EAN 2024

Myasthenia gravis (MG) is an autoimmune disorder where antibodies disrupt the neuromuscular junction, causing muscle weakness that worsens with activity. MG subgroups are based on muscle weakness location, age, antibody type, and thymus pathology, with some patients experiencing severe, treatment-resistant symptoms. Biomarkers can indicate prognosis. First-line treatments include pyridostigmine for symptomatic relief and immunosuppressants like prednisolone and azathioprine. Thymectomy is recommended for certain patients. Second-line treatments include mycophenolate, rituximab, and others, with new therapies like complement and FcRn inhibitors showing promise. Intravenous immunoglobulin and plasma exchange are used for acute exacerbations. Supportive therapy, including adapted exercise, is crucial. In refractory cases, comorbidities and diagnosis accuracy should be reconsidered.

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The European neuromuscular expert working group has published an updated European consensus on the use of gene therapy for the treatment of spinal muscular atrophy (SMA) .

39 mins
CE/CME accredited
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touchIN CONVERSATION
Prof. John Chen, Prof. Friedemann Paul

A neurologist and a neuro-ophthalmologist discuss best practices for early diagnosis and treatment of NMOSD

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Welcome to the latest edition of touchREVIEWS in Neurology. We are excited to present a collection of articles that showcase the latest advancements and diverse perspectives in neurological research and treatment. This issue features insightful reviews and editorials from esteemed ...

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Patrick Schindler, Friedemann Paul

Neuromyelitis optica spectrum disorders (NMOSD) are a group of relapsing autoimmune diseases of the central nervous system. The clinical hallmarks of NMOSD are myelitis and optic neuritis; however, a wider clinical spectrum has been recognized.1 The majority of patients with ...

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Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory autoimmune disease of the central nervous system (CNS) with a worldwide distribution.1 The first clinical description of NMOSD was made a century ago by Devic and Gault, who documented patients with ...

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