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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

Philip Scheltens, EAN 2018 – Evolution of Alzheimer’s disease and dementia

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Published Online: Jun 22nd 2018

Philip Scheltens (EAN Programme Committee; Professor of Cognitive Neurology and Director, Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands) speaks to us following his Edouard Brown-Séquard Lecture during the Presidential Symposium entitled: The evolution of Alzheimer’s disease and dementia.

Questions

1. How have diagnostic criteria evolved in Alzheimer’s disease (AD)? (0:12)
2. What progress has been made in research to identify biomarkers in AD? (0:41)
3. What is your opinion on the concept of mild cognitive impairment to detect early AD? (1:16)
4. Why have so many clinical trials for AD failed? (1:50)
5. What new treatment modalities do you expect to emerge in the coming year? (2:32)

Speaker disclosure: Philip Scheltens has nothing to disclose in relation to this video interview.

Filmed at the 4th Congress of the European Academy of Neurology (EAN), Lisbon, Portugal, June 2018.

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