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The prevalence of unruptured intracranial aneurysms (IAs) is approximately 3% of the population, with incidence on the rise due to the increased utilization of neuro-imaging for diverse objectives.1,2 The average risk of rupture for unruptured IA is estimated to vary from 0.3% to exceeding 15% per 5 years.3 Ruptured IA is the primary aetiology of […]

Gregory Branigan, AAN 2021: Impact of Estrogen Therapies on Alzheimer’s Disease Pathways

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Published Online: May 10th 2021

We were delighted to meet with Gregory Branigan (University of Arizona, AZ, USA) to discuss the impact of estrogen therapies on Alzheimer’s disease pathways.

The abstract entitled: ‘Breast Cancer Therapies Reduce Risk of Alzheimer’s Disease and Dementia: Clinic to Bench Translation’ was presented at the American Academy of Neurology Virtual Annual Meeting 2021.

Questions:

  1. What is the rationale for investigating the impact of estrogen modulating therapy (EMT) exposure on the risk of neurodegenerative disease (NDD) in women with breast cancer? (0:19)
  2. Could you tell us a little about your short study and its findings? (1:46)
  3. What is known about the molecular mechanisms underlying this observed risk reduction? (2:36)
  4. What are the wider implications of these findings? (4:06)
  5. What future studies are planned? (5:08)

Disclosures: Gregory Branigan has nothing to disclose in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch.

Filmed as a highlight of AAN Annual Virtual Meeting 2021.

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