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Motor neuron synapses with muscle fiber via electrical impulse transmission and neurotransmitter release, forming neuromuscular junctions , motor neuron, neuroscience
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

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Seizures are one of the most frequent neurological disorders in neonates − the incidence of seizures in infants born at term is 1–3 per 1,000 live births, and is even higher in both preterm and very-low-birth-weight infants at 1–13 per 1,000 live births.1 Seizures may ...

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Joseph Samaha, Jim Dagher, Shayan Abdollah Zadegan

Huntington’s disease (HD) is a neurodegenerative disease inherited in an autosomal dominant manner. It is caused by an expansion of cytosine, adenine, guanine (CAG) repeats within the huntingtin (HTT) gene, which is located on chromosome 4. This pathological expansion of ...

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A new guideline has been issued to assist neurologists and clinicians in selecting the best anti-seizure medications for people with epilepsy who may become pregnant. Published in Neurology, the guideline is a collaboration between the American Academy of Neurology (AAN), the American Epilepsy Society (AES) and the Society for Maternal-Fetal Medicine (SMFM), with endorsement from the Child Neurology Society. It updates parts of the 2009 AAN and AES guidelines regarding birth malformations and child development in children born to people with epilepsy.

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Posterior reversible encephalopathy syndrome (PRES) is a syndome characterized by a combination of clinical and radiological features.1–3 Its global incidence is unknown. It is underdiagnosed probably due to limited awareness. PRES presents with the rapid onset of neurological symptoms, such ...

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Matthew A Burton, W Alex Dalrymple, Renzo Figari

Myoclonus is defined as a sudden, brief, lightning-like muscle contraction.1 It was first described by Friedreich in 1881 when he detailed sharp jerks involving the bulk of a full muscle without marked limb or joint movement and called it paramyoclonus multiplex.2 ...

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Parkinson’s disease is a progressive synucleinopathy that causes widespread neurodegeneration.1 It is estimated to affect approximately 6.1 million people globally and 0.7–1.0 million people in the USA.2–4 The incidence of the disease is expected to continue to increase over time, and ...

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Cerebral amyloid angiopathy (CAA), also known as congophilic angiopathy, is a recognized cause of lobar intracerebral haemorrhage in patients above the age of 50 years.1 It is known to be due to deposition of a variant of amyloid (beta-amyloid plaque) in ...

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Pavel Klein, Louis Ferrari, William E Rosenfeld

Epilepsy is a very common neurological disease, affecting more than 50 million people worldwide and 3.4 million people in the USA.1–3 Focal seizures, formerly partial-onset seizures, are the most common type, making up ≥60% of cases.4–6 Patients with epilepsy have an increased risk ...

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Simona Lattanzi, Eugen Trinka, Pasquale Striano

Epilepsy is one of the most common neurological disorders, affecting around 70 million people worldwide.1,2 Its management is mainly symptomatic, and long-term seizure remission is achieved in most cases.3,4 One-third of patients, however, continue to experience seizures despite adequate treatment.5 Remarkably, ...

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The International League Against Epilepsy (ILAE) revised its definition of epilepsy in 2014 in order to maximize early identification and treatment of patients with epilepsy.1 The ILAE’s conceptual definition of epilepsy, first formulated in 2005, is “a disorder of the brain ...

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Complex regional pain syndrome, type 1 (CRPS1)/reflex sympathetic dystrophy (RSD) is a neuropathic pain disorder,1 with pain reflecting partially damaged nerve fibers.2 It is normally caused by traumatic injury, further aggravated by neuroinflammation.3 The latter contributes to the devastating potential ...

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Epilepsy is an important cause of disability and mortality, and affects around 50 million people worldwide.1 Focal seizures, which originate in only one part of the brain, account for around 80% of all epileptic seizures.2 Treating epilepsy, however, is challenging since the ...

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Levetiracetam (LEV) is an anti-epileptic drug (AED) indicated for treatment of a broad range of seizure types, of both focal and generalised onset.1 It has many advantages that make it one of most commonly used AEDs. Among the principle ones ...

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Welcome to the latest edition of European Neurological Review, which features a diverse range of articles covering new developments in neurological disease. We begin with one of our popular expert interviews on the subject of headache disorders. Nunu Lund presents ...

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Neuroprotective Strategies in Traumatic Brain Injury Peter JD Andrews Western General Hospital NHS Trust and University of Edinburgh, UK Any severe trauma to the brain results in the activation of a cascade of biochemical pathways and release of chemical mediators. ...

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As the armamentarium of anti-epileptic drugs (AEDs) continues to expand, epilepsy management is becoming increasingly complex. This necessitates multiple considerations for the choice of the most appropriate AED that can broadly be organised into five categories: (i) rational treatment selection (...

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Restless legs syndrome (RLS), or Willis–Ekbom disease (WED), is a sensorimotor disorder having well-known standardised diagnostic criteria1 that have been revised recently by the International Restless Legs Syndrome Study Group.2 The genetic basis of RLS has not been definitively ...

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Epilepsy is one of the most common serious neurological disorders and has far-reaching consequences, not only for patients living with the condition, but also for their families and society as a whole.1 It is useful therefore to evaluate whether the ...

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