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Motor neuron synapses with muscle fiber via electrical impulse transmission and neurotransmitter release, forming neuromuscular junctions , motor neuron, neuroscience
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

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Seizures are one of the most frequent neurological disorders in neonates − the incidence of seizures in infants born at term is 1–3 per 1,000 live births, and is even higher in both preterm and very-low-birth-weight infants at 1–13 per 1,000 live births.1 Seizures may ...

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Molybdenum cofactor deficiency (MoCD) is an ultra-rare genetic disease that remained untreatable until the recent introduction of cyclic pyranopterin monophosphate (cPMP) substitution. This article aims to comprehensively review the rationale behind cPMP substitution, its effectiveness in clinical scenarios, the development ...

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Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder affecting approximately 1 in 10,000 births. It is characterized by predominantly proximal muscle weakness as a result of degeneration of anterior horn cells of the spinal cord.1 In most patients with SMA, the ...

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Report from a Satellite Symposium held at the 28th Annual Congress of the European Society for Intensive Care Medicine, Berlin, Germany, 5 October 2015 Temperature management to avoid fever is standard practice in patients with traumatic brain injury (TBI), subarachnoid haemorrhage and ...

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Modern anaesthetic practice requires the anaesthesiologist to care for extremely sick patients while negotiating the intricacies of myriad procedural environments. One such unique environment that is becoming increasingly important for contemporary anaesthesiologists to be familiar with is that of the ...

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Alzheimer’s disease (AD) is the epitome of a progressive degenerative disease of the brain and culminates in dementia characterised in the beginning stages as a failure to retain new information for appropriate retrieval. As the underlying disease progresses, the ...

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Alzheimer’s disease (AD) is the epitome of a progressive degenerative disease of the brain and culminates in dementia characterized in the beginning stages as a failure to retain new information for appropriate retrieval. As the underlying disease progresses, the ...

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Modern anaesthetic practice requires the anaesthesiologist to care for extremely sick patients while negotiating the intricacies of myriad procedural environments. One such unique environment that is becoming increasingly important for contemporary anaesthesiologists to be familiar with is that of the ...

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