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SOD1-ALS from Gene Discovery to Targeted Therapeutics: A Comprehensive Review

Joshua Newman, Phillipe Corcia, Angela Genge

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

touchREVIEWS in Neurology. 2025;21(1):Online ahead of journal publication

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An Overview of a Stepped-care Approach to Modern Holistic and Subtype-driven Care for Parkinson’s Disease in the Clinic

Karolina Popławska-Domaszewicz, Cristian Falup-Pecurariu, Ray K Chaudhuri

Parkinson’s disease (PD) is characterized by prodromal and clinical stages; the clinical phase is characterized by a constellation of motor and non-motor symptoms (NMS).1 Despite the extensive discussions and publications of the clinical heterogeneity of PD,2 the precise heterogeneous ...

touchREVIEWS in Neurology. 2024;20(1):27-32
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Wellness in Parkinson’s Disease: A Framework for Management Using a Holistic Culturally Sensitive Approach

Indu Subramanian, Kate Perepezko, Britt Stone

In modern medicine, the concept of wellness is accompanied by many misconceptions. Adopting wellness as a treatment approach has been well defined and implemented in cardiovascular disease, diabetes and some types of cancer management but has not yet been widely ...

touchREVIEWS in Neurology. 2023;19(1):8–13 DOI: https://doi.org/10.17925/USN.2023.19.1.8

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