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Motor neuron synapses with muscle fiber via electrical impulse transmission and neurotransmitter release, forming neuromuscular junctions , motor neuron, neuroscience
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

A multi-chamber device for studying neural degeneration

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Published Online: May 4th 2014

NC3Rs-funded researchers, Professor Hugh Perry and Dr Tracey Newman, University of Southampton, have developed a microfluidic device that creates a suitable environment to study what happens during neuronal injury. This better understanding can inform how drugs are tested at the later stages of development, reducing the number of rodents that would be required.

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