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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

James E Galvin, AAIC 2021: Aducanumab for the Treatment of Alzheimer’s Disease

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Published Online: Sep 21st 2021

touchNEUROLOGY joins Prof James Galvin (University of Miami Miller School of Medicine, Miami, FL, USA) to discuss aducanumab for the treatment of Alzheimer’s disease, and what this recent accelerated approval might mean for future potential treatments.

Questions
1. Why has the recent FDA accelerated approval of aducanumab for Alzheimer’s disease been so controversial? (00:13-02:00)
2. Why did the EMERGE clinical study meet its primary endpoint, but the ENGAGE study did not? (02:00-04:21)
3. Which patients are most likely to benefit from aducanumab and in whom should it not be used? (04:21-05:13)
4. What are the consequences of this accelerated approval and how will this impact future research for Alzheimer’s disease? (05:13-08:38)

Disclosures: Prof Galvin has no financial or non-financial conflicts of interest to declare in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Sophie Nickelson.

Filmed in coverage of the 2021 AAIC Annual Meeting.

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