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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

Bart Van Wijmeersch, EAN 2022: Safety of alemtuzumab in patients with multiple sclerosis

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Published Online: Jun 27th 2022

In phase 3 studies, alemtuzumab demonstrated efficacy and safety in patients with relapsing-remitting multiple sclerosis. In an interview with touchNEUROLOGY, Prof. Bart Van Wijmeersch (Universiteit Hasselt and Rehabilitation and MS-Centre Pelt, Belgium) talks through the aims of the alemtuzumab post-authorization safety study, key findings, and insights gained regarding duration of monitoring following treatment with alemtuzumab for multiple sclerosis.

Questions:

  1.  What are the aims of the alemtuzumab post-authorization safety study and what period, post-first exposure, will it cover? (00:18)
  2.  What are the key findings from this interim analysis? (00:48)
  3.  What insight has been gained regarding the necessary duration of monitoring following treatment with alemtuzumab for multiple sclerosis? (01:46)
  4.  Have any risk factors for experiencing treatment-related adverse events with alemtuzumab been identified? (02:47)

The abstract titled ‘Safety of Alemtuzumab in Patients with Multiple Sclerosis: Interim Results of a Post-Authorization Safety Study (PASS)’ (Abstract #EPR-165) was presented at the European Academy of Neurology Congress 2022, 25–28 June 2022.

Disclosures: Bart Van Wijmeersch has received grant/research support from Merck, Sanofi-Genzyme and participated in advisory boards from Almirall, Actelion/Janssen, Bayer, Biogen, Celgene/BMS, Imcyse, Merck, Novartis, Roche, Sanofi-Genzyme and Teva.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Lisa Glass.

Filmed as a highlight of EAN 2022.

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