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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

Bianca Weinstock-Guttman, EAN 2020 – CHORDS Study in RRMS With Suboptimal Prior Response to DMTs

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Published Online: Jun 8th 2020

Bianca Weinstock-Guttman (Jacobs School of Medicine and Biomedical Science, University of Buffalo, NY, USA) shares highlights of her presentation entitled: Effectiveness and safety of ocrelizumab in patients with relapsing-remitting multiple sclerosis who had a suboptimal response with prior disease-modifying therapy: 2-year findings from CHORDS (ClinicalTrials.gov Identifier: NCT02637856).

Questions
1. What are the potential advantages of ocrelizumab in patients with relapsing-remitting multiple sclerosis (MS) compared to other disease-modifying therapies? (
0:05)
2. Could you tell us a little about the aims and design of the CHORDS study? (
1:03)
3. What have been the 2-year efficacy and safety findings of this study, and what was the rate of malignancies in ocrelizumab-treated patients? (
2:33)
4. Which patients are likely to benefit most from ocrelizumab and in whom is it contraindicated? (
3:32)
5. What will be the next step in the clinical development of ocrelizumab? (
4:25)

Speaker disclosure: Bianca Weinstock-Guttman reports receiving grants and/or personal fees from Biogen, EMD Serono, Novartis, Genenech, Malinckrodt, Abbvie and Celgene.

Support: Interview and filming supported by Touch Medical Media.

Filmed at the 6th Congress of the European Academy of Neurology (EAN) and 1st EAN Virtual Congress, May 2020.

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