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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

Joachim Burman, EAN 2019 – Non-myeloablative hematopoietic stem cell transplant in MS: MIST trial

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Published Online: Jul 8th 2019

Joachim Burman (Uppsala University, Sweden) explains to us the rationale for the use of autologous non-myeloablative hematopoietic stem cell transplant (autoHSCT) in patients with relapsing remitting multiple sclerosis, and shares his insight on the MIST (Multiple Sclerosis International Stem cell Transplant) study findings.

Questions
1. What is the rationale for the use of autologous non-myeloablative hematopoietic stem cell transplant (autoHSCT) in patients with relapsing remitting multiple sclerosis? (0:04)
2. Could you tell us a little about the MIST (Multiple Sclerosis International Stem cell Transplant) study and its findings? (0:40)
3. What are the risks of this treatment? (1:44)
4. Which patients are most likely to respond to autoHSCT? (2:43)
5. What were the limitations of the MIST study and what further studies are planned? (3:11)

Speaker disclosure: Joachim Burman has nothing to disclose in relation to this video interview.

Filmed at the 5th Congress of the European Academy of Neurology (EAN), Oslo, Norway, June 2019.

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