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Motor neuron synapses with muscle fiber via electrical impulse transmission and neurotransmitter release, forming neuromuscular junctions , motor neuron, neuroscience
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

Marisa McGinley, AAN 2019 – Latest developments in the treatment of multiple sclerosis

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Published Online: May 29th 2019

Marisa McGinley (Mellen Center, Cleveland Clinic Main Campus, Ohio, USA) shared her expert insights with us on the most significant developments in the treatment of multiple sclerosis (MS) over the past year.

 

Questions
1. What are the current unmet needs in multiple sclerosis (MS) treatment? (0:04)
2. What have been the most important recent advances in the treatment of primary progressive MS? (0:42)
3. Which patients with secondary progressive MS are most likely to benefit from siponimod? (1:11)
4. When should we begin treatment for progressive MS? (2:36)
5. How can quantitative MRI data be used in routine MS clinical practice? (3:51)
6. How important are patient reported outcomes in clinical decision-making? (5:18)

 

Speaker disclosures: Marisa McGinley serves as a consultant for Genzyme and Genentech.

 

Filmed at the American Academy of Neurology (AAN) Annual Meeting, Philadelphia, USA, May 2019.

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