Home > Patrick Vermersch, EAN 2021: Tolebrutinib in Patients with Progressive Multiple Sclerosis: Phase 3 PERSEUS and HERCULES Trials
Multiple Sclerosis

Patrick Vermersch, EAN 2021: Tolebrutinib in Patients with Progressive Multiple Sclerosis: Phase 3 PERSEUS and HERCULES Trials

Published Online: July 22nd 2021

It was a pleasure to meet with Patrick Vermersch (University of Lille, Lille, France) to discuss the use of tolebrutinib in patients with progressive multiple sclerosis.

The abstract entitled: ‘BTK Inhibitor Tolebrutinib in Patients With Progressive MS: Design of Phase 3 PERSEUS and HERCULES Trials’ was presented at the 7th Congress of the European Academy of Neurology – Virtual 2021.

Questions:

  1. What is the rationale for the use of tolebrutinib in patients with progressive multiple sclerosis, and what are their potential advantages compared with anti-CD20 therapy?
  2. What are the aims of the PERSEUS and HERCULES clinical trials?
  3. How do these trials differ in terms of design and eligibility criteria?
  4. What will be the primary outcome measures of the studies?
  5. When are the initial efficacy and safety data expected?

Disclosures: Patrick Vermersch has received honoraria and consulting fees from Biogen, Sanofi-Genzyme, Novartis, Teva, Merck, Roche, Imcyse, AB Science and Celgene; and has received research support from Novartis, Sanofi-Genzyme and Roche.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch

Filmed as a highlight of the EAN Congress, Virtual 2021

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