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Huntington’s disease (HD) is a neurodegenerative disease inherited in an autosomal dominant manner. It is caused by an expansion of cytosine, adenine, guanine (CAG) repeats within the huntingtin (HTT) gene, which is located on chromosome 4. This pathological expansion of CAG repeats results in the production of a mutant huntingtin protein with an abnormally long polyglutamine […]

Patrick Vermersch, MSVirtual2020 – Masitinib in the Treatment of Progressive Multiple Sclerosis (Part 1)

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Published Online: Sep 22nd 2020

Patrick Vermersch (University of Lille and CHU Lille, Lille, France) shares promising findings and expert insight from the phase 3 study of masitinib for the treatment of progressive multiple sclerosis (ClinicalTrials.gov identifier: NCT01433497). This discussion was based on his MSVirtual2020 presentation: FC04.01 Masitinib in primary progressive (PPMS) and non-active secondary progressive (nSPMS) multiple sclerosis: Results from phase 3 study AB07002.

Questions
1. What are unmet needs in the treatment of primary progressive multiple sclerosis (MS) and non-active secondary progressive MS? (0:06)
2. Could you tell us a little about masitinb and its mechanism of action? (2:07)

See also the 2nd part of this interview here.

Disclosures: Dr Vermersch reports receiving honoraria and consulting fees from Biogen, Celgene, Novartis, Sanofi-Genzyme, Merck, Roche and Teva; he also receives research support from Novartis, Roche and Sanofi-Genzyme.

Support: Interview and filming supported by Touch Medical Media.

Filmed as a highlight of the Joint ACTRIMS-ECTRIMS Meeting, MSVirtual2020.

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