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Cognitive impairment is the hallmark symptom of Alzheimer’s disease (AD); however, neuropsychiatric symptoms (NPS), including psychosis, agitation and mood disturbances, are common not only in AD but also in Parkinson’s disease, dementia with Lewy bodies, frontotemporal dementia and vascular dementia.1–5 Psychotic symptoms have been reported to be present in 12–74% of patients with AD, with […]

Patrick Vermersch, MSVirtual2020 – Masitinib in the Treatment of Progressive Multiple Sclerosis (Part 1)

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Published Online: Sep 22nd 2020

Patrick Vermersch (University of Lille and CHU Lille, Lille, France) shares promising findings and expert insight from the phase 3 study of masitinib for the treatment of progressive multiple sclerosis (ClinicalTrials.gov identifier: NCT01433497). This discussion was based on his MSVirtual2020 presentation: FC04.01 Masitinib in primary progressive (PPMS) and non-active secondary progressive (nSPMS) multiple sclerosis: Results from phase 3 study AB07002.

Questions
1. What are unmet needs in the treatment of primary progressive multiple sclerosis (MS) and non-active secondary progressive MS? (0:06)
2. Could you tell us a little about masitinb and its mechanism of action? (2:07)

See also the 2nd part of this interview here.

Disclosures: Dr Vermersch reports receiving honoraria and consulting fees from Biogen, Celgene, Novartis, Sanofi-Genzyme, Merck, Roche and Teva; he also receives research support from Novartis, Roche and Sanofi-Genzyme.

Support: Interview and filming supported by Touch Medical Media.

Filmed as a highlight of the Joint ACTRIMS-ECTRIMS Meeting, MSVirtual2020.

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