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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

Philippe Damier, MDS 2019 – Dyskinesia in Parkinson’s disease

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Published Online: Sep 30th 2019

We were fortunate to have an opportunity to speak with MDS Congress Local Organizing Committee member, Philippe Damier (Centre Hospitalier Universitaire Nantes 2INSERM, Hôpital Laennec, Nantes, France). He discussed dyskinesia in Parkinson’s disease, the topic of the plenary session he chaired.

Questions
1. How common are dyskinesias in Parkinson’s disease (PD) patients and what are their impact on activities of daily living? (0:05)
2. What is known about the role of glutamate and serotonin receptors on dopamine signalling in dyskinesias? (0:48)
3. How do changes in dendritic spines affect the development of dyskinesias? (2:33)
4. What have been the most important recent advances in the management of dyskinesias in PD? (3:22)
5. What are the key take home messages of your session? (4:24)

Speaker disclosure: Philippe Damier has nothing relevant to disclose in relation to this video interview.

Filmed at the International Congress of Parkinson’s Disease and Movement Disorders (MDS), Nice, France, September 2019.

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