The effect of TREM2 on neurodegenerative diagnosis, cognitive profile and brain structure are discussed in this touchNEUROLOGY interview with Dr Oliver Cousins (King’s College London, London, UK). Microglial genes are risk factors for neurodegenerative disease. This study investigated the association between different TREM2 variants and neurodegenerative disease and evaluated their association with brain structure and cognition.
Questions:
- TREM2 variants have been identified as risk factors for several neurological diseases; what is understood about this link? (00:09)
- How do TREM2 variants complicate accurate diagnosis of neurological disease? (01:04)
- What structural and cognitive effects are associated with TREM2 variants? (01:37)
- How can these insights be factored into routine practice, to help optimize diagnosis and monitoring of disease progression? (02:35)
The abstract titled ‘Effect of TREM2 on neurodegenerative diagnosis, cognitive profile and brain structure’ (Abstract #OPR-027) was presented at the European Academy of Neurology Congress 2022, 25–28 June 2022.
Disclosure: Oliver Cousins has nothing to disclose in relation to this video interview.
Support: Interview and filming supported by Touch Medical Media. Interview conducted by Lisa Glass.
Filmed as a highlight of EAN 2022.
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