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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

Stefan Evers, EAN 2019 – Targeting CGRP in the management of headache disorders

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Published Online: Jul 9th 2019

Stefan Evers (University of Münster, Germany), a valued member of our European editorial board, discusses the management of headache disorders with a focus on the new anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies.

Questions
1. What has our experience with ergotamine derivatives and triptans taught us about the pathophysiology of migraine? (0:04)
2. What is the rationale for targeting calcitonin gene-related peptide (CGRP) in the management of headache disorders? (0:43)
3. Which patients are most likely to respond to anti-CGRP monoclonal antibodies and in which patients should they not be used? (1:25)
4. What factors influence your choice of the currently available anti-CGRP monoclonal antibodies? (2:22)
5. What are the possible long-term safety concerns of anti-CGRP monoclonal antibodies? (3:01)

Speaker disclosure: Stefan Evers has nothing to disclose in relation to this video interview.

Filmed at the 5th Congress of the European Academy of Neurology (EAN), Oslo, Norway, June 2019.

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