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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

Stefan Evers, EAN 2019 – Targeting CGRP in the management of headache disorders

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Published Online: Jul 9th 2019

Stefan Evers (University of Münster, Germany), a valued member of our European editorial board, discusses the management of headache disorders with a focus on the new anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies.

Questions
1. What has our experience with ergotamine derivatives and triptans taught us about the pathophysiology of migraine? (0:04)
2. What is the rationale for targeting calcitonin gene-related peptide (CGRP) in the management of headache disorders? (0:43)
3. Which patients are most likely to respond to anti-CGRP monoclonal antibodies and in which patients should they not be used? (1:25)
4. What factors influence your choice of the currently available anti-CGRP monoclonal antibodies? (2:22)
5. What are the possible long-term safety concerns of anti-CGRP monoclonal antibodies? (3:01)

Speaker disclosure: Stefan Evers has nothing to disclose in relation to this video interview.

Filmed at the 5th Congress of the European Academy of Neurology (EAN), Oslo, Norway, June 2019.

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