Dopamine deficiency resulting from the progressive loss of nigrostriatal dopaminergic cells leads to the motor and non-motor impairments associated with Parkinson’s disease (PD). Treatment strategies are focused on dopaminergic replacement therapy. Levodopa monotherapy may be successful in addressing motor symptoms in early-onset patients and may be optimised by adding on other dopamine-potentiating agents such as […]
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Parkinson’s disease (PD) is a complex neurodegenerative condition that predominantly affects older people, with a rising prevalence worldwide.1,2 There are many on-going challenges and unmet needs in PD: difficulties in making an accurate diagnosis (particularly in the early stages of the disease), troubling side effects associated with the available pharmacological treatments, a lack of effective disease-modifying therapies […]
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European Neurological Review is a peer-reviewed, free-to-access, bi-annual neurology journal comprising review articles, case reports, practice guides, theoretical discussions, and original research. It features balanced and comprehensive articles written by leading authorities, addressing the most important and salient developments in the field of neurology in practical terms.
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