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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

Anthony Béhin, EAN 2023: Safety Profile Overview of Efgartigimod Clinical Trials in Participants With Diverse IgG-Mediated Autoimmune Diseases

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Published Online: Jul 28th 2023

Dr Anthony Béhin (University Hospitals Pitié Salpêtrière, Paris, France) discusses his abstract on the safety profile of anti-FcRn drugs, in particular efgartigimod, and anti-complement drugs in the treatment of IgG-mediated autoimmune diseases.

The abstract ‘EPR-128 Safety Profile Overview of Efgartigimod Clinical Trials in Participants With Diverse IgG-Mediated Autoimmune Diseases’ was presented at the annual European Academy of Neurology (EAN), July 1–4, 2023

Questions

1. Please can you summarize the safety profile of anti-FcRn drugs, in particular efgartigimod, in IgG-mediated autoimmune diseases (00:26)
2. Please summarize the safety and efficacy profile of anti-complement drugs in the treatment of IgG-mediated autoimmune diseases (04:42)

Disclosures: Anthony Béhin is a consultant for Alexion, Argenx, UCB, Sanofi and Ultragenyx pharmaceutical. He has received grant/research support from the Association Institut de Myologie and is on the advisory board for Alexion, Argenx, UCB, Sanofi and Ultragenyx pharmaceutical. He has received honoraria/honorarium from Alexion, Argenx, UCB, Sanofi and Ultragenyx. pharmaceutical

Support: Interview and filming was supported by Touch Medical Media. The interview was conducted by Sophie Nickelson.

Filmed as highlight of EAN 2023.

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