Jeffrey Guptill, AAN 2021: Vivacity-MG Study Results
We were delighted to meet with Jeffery Guptill (Duke University Medical Center, Durham, NC, USA) to discuss the Vivacity-MG study results (NCT03772587), investigating nipocalimab as a treatment option for Myasthenia Gravis.
The abstract entitled: ‘Vivacity-MG: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Efficacy, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Nipocalimab Administered to Adults with Generalized Myasthenia Gravis’ was presented at the American Academy of Neurology Virtual Annual Meeting 2021.
- What are the limitations of broad based immunotherapies in the treatment of myasthenia gravis (MG)? (0:18)
- What is nipocalimab and what is its mechanism of action? (2:52)
- Could you tell us a little about the Vivacity study and its efficacy and safety findings to date? (3:21)
- What questions remain unanswered about the clinical utility of nipocalimab in this treatment setting and what future studies are planned? (5:32)
- Where do you think nipocalimab will sit in the treatment paradigm for MG? (7:02)
Disclosures: Jeffrey Guptill is a consultant in past 12 months for Immunovant, Alexion, Apellis, Momenta, Ra Pharma, Grifols, Jacobus, Becton Dickinson, Cabaletta, Regeneron, Argenx, UCB, Toleranzia and Piedmont Pharmaceuticals; receives industry grant support from UCB pharma for a fellowship training grant. Full disclosure statement available at: https://dcri.org/about-us/conflict-of-interest/. Jeffrey Guptill is also a site investigator for: Alexion, Momenta, Ra Pharma, Argenx, Takeda, and receives grant/research support from: NIH (NIAID, NINDS, NIMH), and Myasthenia Gravis Foundation of America.
Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch,
Filmed as a highlight of AAN Annual Virtual Meeting 2021
Share this Video
Related Videos In Neuromuscular Diseases
Francesco Saccà, EAN 2022: Improving quality of life for patients with generalized myasthenia gravis – ADAPT trial findings
The ADAPT trial (NCT03669588) supported US Food and Drug Administration approval of efgartigimod alfa-fcab in generalized myasthenia gravis. Dr Francesco Saccà (University of Naples Federico II, Naples, Italy) discussed the findings of the study, in terms of health-related quality-of-life outcomes. Questions: 1. What are the current challenges in managing cases of generalized myasthenia gravis? (00:14) […]
James Howard AAN 2022: Ravulizumab for adults with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis – Results from the phase 3 CHAMPION-MG OLE trial
Ravulizumab has recently been approved by in the US for the treatment of adults with anti-acetylcholine receptor antibody-positive (AChR Ab+) generalized myasthenia gravis (gMG). Prof. James Howard (The University of North Carolina at Chapel Hill, NC, USA) kindly joins touchNEUROLOGY to discuss the phase 3 CHAMPION-MG trial open label extension study that evaluated the efficacy and […]
James Howard, AAN 2022: Unmet needs in the treatment of myasthenia gravis
Myasthenia gravis (MG) is a rare autoimmune disorder caused by antibodies that act against the myoneural junction, resulting in weakness of the skeletal muscles. Prof. James Howard (The University of North Carolina at Chapel Hill, CA, USA) discusses the unmet needs in the treatment of this rare disease, including, quality of life of patients, response to […]
Journal articles and more to your inbox
Get the latest clinical insights from touchNEUROLOGYSign me up!