Neuromuscular Diseases, Rare Diseases
Watch Time: 08:34 mins

Francesco Saccà, EAN 2022: Improving quality of life for patients with generalized myasthenia gravis – ADAPT trial findings

Published Online: July 8th 2022

The ADAPT trial (NCT03669588) supported US Food and Drug Administration approval of efgartigimod alfa-fcab in generalized myasthenia gravis. Dr Francesco Saccà (University of Naples Federico II, Naples, Italy) discussed the findings of the study, in terms of health-related quality-of-life outcomes.

Questions:

1. What are the current challenges in managing cases of generalized myasthenia gravis? (00:14)

2. What did the ADAPT trial aim to demonstrate in patients with generalized myasthenia gravis? (02:21)

3. What effect on patient quality of life has efgartigimod demonstrated? (04:16)

4. How will these findings translate into care strategies for generalized myasthenia gravis? (05:35)

The abstract titled ‘Efgartigimod improved quality-of-life in gMG: a randomised, double-blinded, placebo-controlled, phase 3 trial (ADAPT)’ (Abstract #EPR-097) was presented at the European Academy of Neurology Congress 2022, 25–28 June 2022.

Disclosures: Francesco Saccà has participated in advisory boards for Alexion, Almirall, Argenx, Avexis, Biogen, Forward Pharma, Lexeo Therapeutics, Merk, Novartis, Novatek, Roche, Sanofi and Takeda; and received  honoraria from Alexion, Argenx, Biogen, Mylan, Novartis, Roche, Sanofi and Teva.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Lisa Glass.

Filmed as a highlight of EAN 2022.

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