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Huntington’s disease (HD) is a neurodegenerative disease inherited in an autosomal dominant manner. It is caused by an expansion of cytosine, adenine, guanine (CAG) repeats within the huntingtin (HTT) gene, which is located on chromosome 4. This pathological expansion of CAG repeats results in the production of a mutant huntingtin protein with an abnormally long polyglutamine […]

Renato Mantegazza, EAN 2021: Phase 3 ADAPT Study Results

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Published Online: Jul 5th 2021

touchNEUROLOGY met with Renato Mantegazza (Department of Neuroimmunology and Neuromuscular Diseases, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Milan, Italy), to discuss the phase 3 ADAPT study results investigating efgartigimod for the treatment of myasthenia gravis.

The abstract entitled: ‘Safety and Tolerability of Efgartigimod in Patients with Generalized Myasthenia Gravis: Phase 3 ADAPT Study Results’ was presented at the 7th Congress of the European Academy of Neurology – Virtual 2021.

Questions:

  1. Could you tell us a little about efgartigimod and its mechanism of action? (0:19)
  2. Could you give us a brief overview of the ADAPT study objectives and its findings? (2:04)
  3. What are the potential side effects of efgartigimod? (3:50)
  4. What role is efgartigimod likely to play in the treatment paradigm of myasthenia gravis, and what further study is needed? (4:46)

Disclosures: Renato Mantegazza has received funding for Travel or Meeting attendance from, Alexion, Argenx, Biomarin Novartis, Catalyst, Merck Serono, UCB, and for Advisory Board participation from Alexion, Argenx, UCB, Regeneron.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch

Filmed as a highlight of the EAN Congress, Virtual 2021

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