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Joseph Samaha, Jim Dagher, Shayan Abdollah Zadegan

Huntington’s disease (HD) is a neurodegenerative disease inherited in an autosomal dominant manner. It is caused by an expansion of cytosine, adenine, guanine (CAG) repeats within the huntingtin (HTT) gene, which is located on chromosome 4. This pathological expansion of CAG repeats results in the production of a mutant huntingtin protein with an abnormally long polyglutamine […]

José A. López García, EAN 2021: Clinical Development of SAN711, and its Potential to Treat Neuropathic Pain

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Published Online: Aug 9th 2021

It was a pleasure to meet with José A. López García (University of Alcalá, Alcalá de Henares, Spain) to discuss the clinical development of SAN711, a selective GABAA α3 receptor positive allosteric modulator for the potential treatment of neuropathic pain.

The abstract entitled: ‘SAN711 a selective GABAA α3 receptor positive allosteric modulator as a novel treatment for trigeminal neuralgia ’ was presented at the 7th Congress of the European Academy of Neurology – Virtual 2021.

Questions:

  1. Could you tell us a little about SAN711, its selectivity and mechanism of action? (0:16)
  2. What are the objectives and design of the Phase 1 study of SAN711? (8:53)
  3. What are the intended clinical indications of SAN711? (10:55)

Disclosures: José A. López García has nothing to disclose in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Katey Gabrysch

Filmed as a highlight of the EAN Congress, Virtual 2021

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