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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

Philippe Damier, MDS 2019 – Dyskinesia in Parkinson’s disease

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Published Online: Sep 30th 2019

We were fortunate to have an opportunity to speak with MDS Congress Local Organizing Committee member, Philippe Damier (Centre Hospitalier Universitaire Nantes 2INSERM, Hôpital Laennec, Nantes, France). He discussed dyskinesia in Parkinson’s disease, the topic of the plenary session he chaired.

Questions
1. How common are dyskinesias in Parkinson’s disease (PD) patients and what are their impact on activities of daily living? (0:05)
2. What is known about the role of glutamate and serotonin receptors on dopamine signalling in dyskinesias? (0:48)
3. How do changes in dendritic spines affect the development of dyskinesias? (2:33)
4. What have been the most important recent advances in the management of dyskinesias in PD? (3:22)
5. What are the key take home messages of your session? (4:24)

Speaker disclosure: Philippe Damier has nothing relevant to disclose in relation to this video interview.

Filmed at the International Congress of Parkinson’s Disease and Movement Disorders (MDS), Nice, France, September 2019.

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