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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

Roger McIntyre – Psilocybin-based Therapies in Mood Disorders

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Published Online: Jul 21st 2020

TouchNEUROLOGY caught up with Roger McIntyre (University Toronto, Ontario, Canada) to discuss psychedelics, and in particular psilocybin-based therapies, and their potential in the treatment of mood disorders.

Questions

1. Please could you give us a brief overview of psilocybin and its action on serotonergic (5-HT) pathways? (0:04)

2. Which conditions are most likely to benefit from psilocybin therapy? (0:48)

3. What are the major challenges in bringing psilocybin-based products to the market? (1:57)

4. Could you tell us a little about the products you are working with and the current research activities? (3:18)

5. What will be the next steps in the development of psilocybin-based therapies? (4:38)

Speaker Disclosure: Roger McIntyre has acted as a consultant and/or received research support from Lundbeck, Janssen, Shire, Purdue, Pfizer, Otsuka, Allergan, Takeda, Neurocrine, Sunovion, Minerva, Intra-Cellular Pharmaceuticals, Stanley Medical Research Institute, and CIHR/GACD/National Natural Science Foundation of China. He is CEO of Champignon, which acquired the Canadian Rapid Treatment Centre of Excellence.

Support: Interview and filming supported by Touch Medical Media.

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