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Huntington’s disease (HD) is a neurodegenerative disease inherited in an autosomal dominant manner. It is caused by an expansion of cytosine, adenine, guanine (CAG) repeats within the huntingtin (HTT) gene, which is located on chromosome 4. This pathological expansion of CAG repeats results in the production of a mutant huntingtin protein with an abnormally long polyglutamine […]

Daniel Hanley, AAN 2019 – MISTIE III study insights

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Published Online: May 29th 2019

US Neurology Editorial Board member, Daniel Hanley (Johns Hopkins Medicine, Baltimore, Maryland, USA), provides his positive insights on MISTIE III, a clinical trial investigating the efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral hemorrhage evacuation, which failed to meet its primary endpoint of improved functional outcome at 1 year.

 

Questions
1. Could you tell us a little about the MISTIE procedure for the surgical removal of spontaneous intracerebral hemorrhage? (0:04)
2. What were the findings of the MISTIE III study? (1:14)
3. What lessons have been learned from MISTIE III and what will be the next steps in this research (3:12)
4. What are your hopes for the future of this research? (4:52)

 

Speaker disclosures: Daniel Hanley has nothing to disclose in relation to this video interview.

 

Filmed at the American Academy of Neurology (AAN) Annual Meeting, Philadelphia, USA, May 2019.

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