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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

Advances in Treating Huntington’s Disease

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Published Online: Jun 10th 2014

One project is called PADDINGTON, where researchers of Siena Biotech in Italy have developed a new compound that binds to the toxic protein of Huntington’s Disease and disables it. This could slow down the progression of the disease, and preliminary clinical tests are underway.

The second research endeavour is called NEUROSTEMCELLS, where a team in Milan led by Professor Elena Cattaneo studies how the neurons in Huntington’s patients are lost. The researchers want to use stem cells to grow exactly those neurons which are being lost by the disease. Their vision: to use these lab-grown neurons one day for experimental transplants.

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