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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons that results in progressive motor impairment. ALS is the most common disease of motor neurons with an annual incidence of approximately 1.7–2.5 per 100,000 people. It is a terminal condition with a typical life expectancy of 2–5 years from symptom onset. […]

Advances in Treating Huntington’s Disease

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Published Online: Jun 10th 2014

One project is called PADDINGTON, where researchers of Siena Biotech in Italy have developed a new compound that binds to the toxic protein of Huntington’s Disease and disables it. This could slow down the progression of the disease, and preliminary clinical tests are underway.

The second research endeavour is called NEUROSTEMCELLS, where a team in Milan led by Professor Elena Cattaneo studies how the neurons in Huntington’s patients are lost. The researchers want to use stem cells to grow exactly those neurons which are being lost by the disease. Their vision: to use these lab-grown neurons one day for experimental transplants.

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