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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

Celia Oreja-Guevara, EAN 2020 – Regional Findings From The Phase 3 PREVENT Study in NMOSD

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Published Online: Jun 8th 2020

Great to have an opportunity to speak with Celia Oreja-Guevara (University Hospital San Carlos and University Complutense, Madrid, Spain) around the highlights of her presentation entitled: Regional outcomes of eculizumab treatment in patients with aquaporin-4 immunoglobin G-positive neuromyelitis optica spectrum disorder: findings from the phase 3 PREVENT study (ClinicalTrials.gov Identifier: NCT01892345).

Questions 1. What were the aims of the PREVENT study? (0:05)
2. What were the baseline regional differences in patient characteristics and use of immunosuppressive therapies? (
0:45)
3. What were the outcomes across different regions? (
2:50)
4. What is the broader significance of these findings? (
4:24)

Speaker disclosure: Celia Oreja-Guevara reports that research funding for the study discussed in this video interview was provided by Alexion Pharmaceuticals.

Support: Interview and filming supported by Touch Medical Media.

Filmed at the 6th Congress of the European Academy of Neurology (EAN) and 1st EAN Virtual Congress, May 2020.

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