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Why this topic matters Autoimmune psychosis (AP) is conceptualized as a psychosis-dominant form of autoimmune encephalitis (AE). In contrast to ‘typical’ AE, in which seizures, impaired consciousness and focal deficits rapidly declare a neurological syndrome, patients with AP can initially present to psychiatric services with apparently isolated psychotic or mood symptoms. Overt neurological signs may […]

Rebecca Gilbert AAN, 2021: Update on Clinical Trials in Parkinson’s and Huntington’s Diseases

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Published Online: May 27th 2021

We were pleased to meet with one of our valued Editorial Board Members, Rebecca Gilbert, MD, PhD (American Parkinson Disease Association, Staten Island, NY, USA) to discuss highlights from the AAN session entitled ‘Update on Clinical Trials in Parkinson’s and Huntington’s Diseases’ presented at the American Academy of Neurology Virtual Annual Meeting 2021.

Questions:

  1. In terms of disease-modifying interventions in Parkinson’s disease (PD), what have been the most exciting clinical trial findings in the last year? (0:15)
  2. What criteria should be used to identify patients who may benefit most from PD disease modifying interventions? (4:05)
  3. Could you give us a brief overview of recently completed and on-going clinical trials in Huntington’s disease? (5:52)
  4. Following the recent decision to discontinue dosing in the Phase III GENERATION HD1 study of tominersen in HD, what does the future hold for huntington-lowering as a potential treatment approach? (8:04)

Disclosures: Rebecca Gilbert has nothing to disclose in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview was conducted by Katey Gabrysch. Filmed as a highlight of AAN Annual Virtual Meeting 2021

Filmed as a highlight of AAN Annual Virtual Meeting 2021.

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