Sleep is essential to human health, but its function, physiology, and pathophysiology have been poorly understood until relatively recently. As well as having negative consequences in social and working life, sleep disturbances and disorders have been associated with neurocognitive disorders, hypertension, dyslipidaemia, cardiovascular disease, weight-related issues, metabolic syndrome, type 2 diabetes, depression and stroke. More than 80 sleep disorders have been identified, some of which very common, including insomnia and obstructive sleep apnoea. Sleep abnormalities are also a common consequence of neurological disorders such as Alzheimer’s disease and Parkinson’s disease. Behavioural treatments have been successful in treating sleeping disorders, while pharmacotherapy is useful for acute insomnia, some parasomnias, narcolepsy and idiopathic hypersomnia.
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Narcolepsy is a chronic clinical condition primarily characterized by excessive daytime sleepiness (EDS). This may be accompanied by cataplexy, which is a phenomenon of transient muscle weakness triggered by strong emotions, such as laughter, excitement, anger or grief. Narcolepsy is ...
Leading sleep medicine experts explore strategies for the optimal management of excessive daytime sleepiness associated with obstructive sleep apnea or narcolepsy.
Ambra Stefani was born in Italy, where she performed her medical training at the University of Verona. After that she moved to Innsbruck, Austria, where she is currently working as resident and PhD student in the Department of Neurology, Medical ...
Highlights Neuromuscular diseases exhibit a complex array of respiratory physiologic changes that typically progress over time. These physiologic changes can promote significant respiratory abnormalities during sleep, leading to decreased quality of life, significant daytime symptoms, and overall worse survival. ...
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