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Joseph Samaha, Jim Dagher, Shayan Abdollah Zadegan

Huntington’s disease (HD) is a neurodegenerative disease inherited in an autosomal dominant manner. It is caused by an expansion of cytosine, adenine, guanine (CAG) repeats within the huntingtin (HTT) gene, which is located on chromosome 4. This pathological expansion of CAG repeats results in the production of a mutant huntingtin protein with an abnormally long polyglutamine […]

Heinz Reichmann, MDS 2020 – Gut Microbiome and Parkinson’s Disease

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Published Online: Sep 23rd 2020

As always, we were pleased to have the opportunity to catch-up with valued editorial board member Heinz Reichmann (Technische Universität Dresden, Dresden, Germany), who spoke to us on the topic of the lecture he gave during the on-demand sessions entitled: The Gut Microbiome in the Pathogenesis of Parkinson’s Disease.

Questions
1. Could you tell us about the association between constipation and Parkinson’s disease (PD)? (0:06)
2. Could you give us an overview of the evidence supporting the hypothesis that α-synuclein pathology originates in the gut and spreads to the enteric nervous system? (0:33)
3. What have these findings taught us about the cause of PD? (1:16)
4. Could you give us an overview of the key scientific data supporting a role of the gut microbiome in the development of PD? (2:15)
5. How can these findings potentially be used to improve treatment? (3:20)

Disclosures: Prof. Reichmann has no financial or non-financial relationships or activities to declare in relation to this video interview.

Support: Interview and filming supported by Touch Medical Media.

Filmed as a highlight of the International Parkinson and Movement Disorder Society MDS Virtual Congress 2020.

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