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Joseph Samaha, Jim Dagher, Shayan Abdollah Zadegan

Huntington’s disease (HD) is a neurodegenerative disease inherited in an autosomal dominant manner. It is caused by an expansion of cytosine, adenine, guanine (CAG) repeats within the huntingtin (HTT) gene, which is located on chromosome 4. This pathological expansion of CAG repeats results in the production of a mutant huntingtin protein with an abnormally long polyglutamine […]

Martin Brodie, CONy 2020 – Combination Antiepileptic Drug Therapy

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Published Online: Dec 18th 2020

It was a pleasure to speak with Martin Brodie (President, International Bureau for Epilepsy and co-Section Head of Epilepsy for CONy), who spoke with us on the topic of the debate session he participated in: Should combination antiepileptic drug (AED) therapy be offered immediately after failure of a single antiepileptic drug?

Questions

  1. Could you tell us a little about the current standard of care and the unmet need in the treatment of epilepsy? (0:08)
  2. What evidence supports the use of combination antiepileptic drug therapy and how should it be introduced? (1:48)
  3. If combination therapy is used, how do we best optimise the outcome? (3:45)
  4. What are the potential side effects of antiepileptic drug therapy and how can they be minimised? (5:40)
  5. What other factors should be considered to optimise polytherapy in patients with epilepsy? (7:07)

Support: Interview and filming supported by Touch Medical Media Ltd.

Disclosures: Martin Brodie has nothing to disclose in relation to this video

Filmed in coverage of the 14th World Congress on Controversies in Neurology (CONy Virtual, November 2020).

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