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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

Martin Brodie, CONy 2020 – Combination Antiepileptic Drug Therapy

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Published Online: Dec 18th 2020

It was a pleasure to speak with Martin Brodie (President, International Bureau for Epilepsy and co-Section Head of Epilepsy for CONy), who spoke with us on the topic of the debate session he participated in: Should combination antiepileptic drug (AED) therapy be offered immediately after failure of a single antiepileptic drug?

Questions

  1. Could you tell us a little about the current standard of care and the unmet need in the treatment of epilepsy? (0:08)
  2. What evidence supports the use of combination antiepileptic drug therapy and how should it be introduced? (1:48)
  3. If combination therapy is used, how do we best optimise the outcome? (3:45)
  4. What are the potential side effects of antiepileptic drug therapy and how can they be minimised? (5:40)
  5. What other factors should be considered to optimise polytherapy in patients with epilepsy? (7:07)

Support: Interview and filming supported by Touch Medical Media Ltd.

Disclosures: Martin Brodie has nothing to disclose in relation to this video

Filmed in coverage of the 14th World Congress on Controversies in Neurology (CONy Virtual, November 2020).

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