Home > Michael Sperling, AAN 2021: Post-hoc Analysis of Cenobamate for Uncontrolled Focal Seizures
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Michael Sperling, AAN 2021: Post-hoc Analysis of Cenobamate for Uncontrolled Focal Seizures

Published Online: April 22nd 2021

We were delighted to speak with Michael Sperling (Thomas Jefferson University, Philadelphia, PA, USA) to discuss the recent post-hoc analysis of cenobamate for uncontrolled focal seizures, and its intended place in the treatment landscape for epilepsy.

The abstract entitled: ‘Efficacy of Cenobamate for Uncontrolled Focal Seizures: Post-hoc Analysis of a Phase 3, Multicenter, Open-Label Study’ was presented at the American Academy of Neurology Virtual Annual Meeting 2021.

Questions:

  1. What did the findings of the recent global, open-label phase 3 study teach us about the efficacy and safety of cenobamate? (0:15)
  2. What is the rationale for the dose escalating strategy with cenobamate? (5:45)
  3. What was the rationale for the post-hoc analysis? (6:47)
  4. What were the findings of this analysis? (7:41)
  5. What questions remain unanswered? (8:45)

Disclosures: Michael Sperling has received compensation for speaking at CME programs from Neurology Live, Medscape, Projects for Knowledge, International Medical Press, Eisai, and UCB Pharma; and is an advisor for scientific publications for Neurelis; consults for Medtronic with payments to Thomas Jefferson University; and has received research support from Eisai; Medtronic; Neurelis; SK Life Science; Takeda; Xenon; Cerevel; UCB Pharma; and Engage Pharmaceuticals.

Support: Interview and filming supported by Touch Medical Media.

Filmed as a highlight of AAN Annual Virtual Meeting 2021.

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