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Cognitive impairment is the hallmark symptom of Alzheimer’s disease (AD); however, neuropsychiatric symptoms (NPS), including psychosis, agitation and mood disturbances, are common not only in AD but also in Parkinson’s disease, dementia with Lewy bodies, frontotemporal dementia and vascular dementia.1–5 Psychotic symptoms have been reported to be present in 12–74% of patients with AD, with […]

Pat Penovich, AES 2020 – The Patient Experience With Diazepam Nasal Spray

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Published Online: Dec 18th 2020

It was a pleasure to talk to Pat Penovich (Minnesota Epilepsy Group, St. Paul, MN, USA) about the exit survey, of a Phase 3 study, assessing patient experience of using the diazepam nasal spray for seizure clusters. The abstract ‘Examining the Patient Experience With Diazepam Nasal Spray for Seizure Clusters: Patient-reported Results From an Exit Survey of a Phase 3, Open-label, Repeat Dose Safety Study.’ was presented at the virtual AES 2020, 4-8 December 2020.

Questions

  1. What are the advantages of intranasal delivery of rescue medications compared with current options in patients with epilepsy clusters? (0:05)
  2. Could you tell us a little about the diazepam nasal spray and it’s indications? (1:36)
  3. Could you give us an overview of your recent study on patient experience with diazepam nasal spray? (2:44)
  4. What were the findings of the study and what are the implications for future clinical practice? (3:50)
  5. Which patients are most likely to benefit from the diazepam nasal spray? (5:12)

Disclosures: Consultant and on Speaker’s Bureau for Neurelis, SK and UCB; Speaker’s Bureau for Greenwich; and Consultant for Marinus and LVIS.

Support: Interview and filming supported by Touch Medical Media.

Filmed as a highlight of AES 2020, 4-8 December, 2020 (Virtual).

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