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Joseph Samaha, Jim Dagher, Shayan Abdollah Zadegan

Huntington’s disease (HD) is a neurodegenerative disease inherited in an autosomal dominant manner. It is caused by an expansion of cytosine, adenine, guanine (CAG) repeats within the huntingtin (HTT) gene, which is located on chromosome 4. This pathological expansion of CAG repeats results in the production of a mutant huntingtin protein with an abnormally long polyglutamine […]

Tim J von Oertzen, EAN 2020 – Multiple SISCOM in Presurgical Evaluation of Drug-refractory Epilepsy

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Published Online: May 28th 2020

Tim J von Oertzen (Kepler Universitätsklinikum, Linz, Austria) describes interim findings that highlight the promising utility of multiple subtraction ictal SPECT coregistered to MRI (SISCOM) to guide presurgical evaluation of patients with drug-refractory epilepsy.

Questions
1. What are the major challenges in the presurgical evaluation of candidates with drug-refractory epilepsy? (
0:05)
2. Could you give us a brief overview of SISCOM and its utility in demonstrating blood flow changes during seizures? (
0:48)
3. Could you tell us a little about the rationale and aims of your study investigating hyperperfusion zones in multiple SISCOMs and the correlation with surgical site and post-surgical outcomes? (
3:02)
4. What were the outcomes of this study? (
4:36)
5. What have we learned from these findings and what future studies are planned? (
5:57)

Speaker disclosure: Tim J von Oertzen has nothing to disclose in relation to this video interview.

Support: Interview and filming supported by Touch Medical Media.

Filmed at the 6th Congress of the European Academy of Neurology (EAN) and 1st EAN Virtual Congress, May 2020.

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