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Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of both upper and lower motor neurons, which ultimately leads to muscle weakness, atrophy, spasticity and contractures.1 ALS typically manifests in the 50–60 years age range, although familial cases may present in late adolescence or early adulthood.2 The time from the first symptom to diagnosis is approximately 10–16 […]

Tim J von Oertzen, EAN 2020 – Multiple SISCOM in Presurgical Evaluation of Drug-refractory Epilepsy

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Published Online: May 28th 2020

Tim J von Oertzen (Kepler Universitätsklinikum, Linz, Austria) describes interim findings that highlight the promising utility of multiple subtraction ictal SPECT coregistered to MRI (SISCOM) to guide presurgical evaluation of patients with drug-refractory epilepsy.

Questions
1. What are the major challenges in the presurgical evaluation of candidates with drug-refractory epilepsy? (
0:05)
2. Could you give us a brief overview of SISCOM and its utility in demonstrating blood flow changes during seizures? (
0:48)
3. Could you tell us a little about the rationale and aims of your study investigating hyperperfusion zones in multiple SISCOMs and the correlation with surgical site and post-surgical outcomes? (
3:02)
4. What were the outcomes of this study? (
4:36)
5. What have we learned from these findings and what future studies are planned? (
5:57)

Speaker disclosure: Tim J von Oertzen has nothing to disclose in relation to this video interview.

Support: Interview and filming supported by Touch Medical Media.

Filmed at the 6th Congress of the European Academy of Neurology (EAN) and 1st EAN Virtual Congress, May 2020.

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