Multiple Sclerosis
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Your Patients with Multiple Sclerosis have Set Wellness as a High Priority— And the National Multiple Sclerosis Society is Responding

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Published Online: Nov 6th 2015 US Neurology, 2015;11(2):80–6 DOI:
Authors: Maura Dunn, Pavan Bhargava, Rosalind Kalb
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Over the past few years, the National Multiple Sclerosis Society (Society) has been analyzing topics of importance to the MS community across a variety of communication channels. The data show a trend toward decreased trust in pharmacologic approaches and increased interest in more holistic approaches to MS treatment. People living with MS want to know what they can do today—particularly related to diet, exercise, and emotional wellness—to feel and function at their best. In addition, they want the support of knowledgeable healthcare professionals who are armed with accurate information about wellness interventions. This article reports the findings and conclusions from a recent meeting convened by the Society, during which clinicians, researchers, people with MS, and Society staff reviewed what is currently known about diet, exercise, and emotional issues in MS; identified key questions to be answered in each of these domains, along with the research gaps and challenges to be addressed to arrive at the answers; made specific programmatic recommendations to ensure that people living with MS are getting the personalized support and information they need to achieve wellness; and determined next steps to move this important priority forward, some of which are already underway.


Multiple sclerosis, National Multiple Sclerosis Society, wellness, exercise, diet, emotion, depression, intervention, research, programs


Achieving wellness is a high priority for people living with multiple sclerosis (MS). They want to know what they can do today to feel their best, and whether lifestyle interventions can impact the course of the disease. People with MS are also among the most informed, engaged, and self-advocating patients with chronic illness—proactively seeking information through a variety of channels.1

The National MS Society (Society) has observed trends and emerging topics within the MS community for the past few years. One strategy for evaluating interest in certain topics is by analyzing trends in “conversations” over time. We track topics in traditional media, social media, website traffic, and calls to our Information Resource Center (IRC) on a regular basis. We then mine the data collected to find consistencies and inconsistencies (over time, among channels, between specific populations, etc.), explore the meaning behind trends, and determine the Society’s response.

Trends and Topics in the Multiple
Sclerosis Community
Social Listening

Social listening, which is primarily utilized as a marketing and public relations tool, is the process of identifying and assessing what is being said about a topic, company, individual, or brand on the Internet. Billions of conversations occurring daily—on blogs, message boards, forums, social networks, wikis, microblogs, video sites, online news sources, and more—produce massive amounts of unstructured data. Listening and analytics platforms use keywords to provide structure to the unstructured social data through the use of “smart algorithms.” Essentially, the software transposes specific words or phrases in unstructured data into numerical values that are linked to structured data in a database. The structured data can then be analyzed with traditional data-mining techniques. Social listening provides an opportunity to tap into day-to-day conversations among people with MS in real time, on a global scale— something that is not possible in traditional medical and research settings.

Website Traffic
The Society’s website,, is an online resource for people living with and affected by MS and healthcare professionals. The site is updated regularly based on research, best practices, and visitor feedback. With more than 16,000 pages of content, the site averages approximately 450,000 monthly visitors, 80 % of whom have MS or have a loved one with MS. Recent usability tests revealed that treating MS, understanding or managing symptoms, and fulfilling financial needs are the top priorities for website visitors.

Call Center Interactions
The Society’s IRC is made up of a team of human services professionals providing intake and assessment as well as information and referral services to people living with MS. The goal for of the IRC is to help each person affected by MS to get timely, accurate information and counsel to manage the disease and maintain and enhance independence and quality of life. In 2014, the IRC received approximately 171,000 calls and 11,500 emails. The most frequent requests include resources for emotional support and wellness, referrals to healthcare professionals with knowledge and experience in MS, and solutions to address the financial impact of MS.

Insights We Have Gained
In spite of dips and spikes over the past few years, interest in wellness strategies for MS symptom management has remained consistently high.

Our preliminary data, including correlations between frequency of symptom- and wellness-related keyword usage, suggest that people with MS are looking to wellness-focused approaches to managing symptoms of MS (see Figure 1). They are trying to solve difficult problems for which we have inconsistent solutions.

Over the past few years, we have seen a trend toward decreased trust in pharmacologic approaches and increased interest in more holistic approaches to MS treatment.

When opinion leaders—such as celebrities and key MS bloggers—begin showing interest in a topic, including wellness strategies, it tends to get more traditional and social media attention.

We have learned from other high-profile topics, such as chronic cerebral venous insufficiency (CCSVI), stem cell treatments, and cannabis, that when patients feel that their healthcare providers and the Society have not adequately addressed their questions, they are more likely to turn to anecdotal information—potentially putting themselves at risk.

Three areas of wellness are of special interest to people with MS. They want to know how they can manage their MS with diet and with exercise (see Figure 2). From our strategic planning outreach activities and our targeted daily listening around symptoms, we also know that people with MS want to learn how to manage mood changes—particularly depression—and develop strategies to achieve emotional wellness. It is interesting to note that information about disease-modifying therapies falls relatively low on the priority list, perhaps because they already have many sources of information about MS treatments.

Doctor–Patient Dialogue around Wellness
Healthcare professionals are also concerned about their patients’ wellness, but face significant challenges in providing guidance or intervention: limited time to cover all that needs to be covered in an office visit, lack of robust data to guide recommendations in the areas of diet and exercise, a don’t ask/don’t tell conundrum in the area of mood disorders, and inadequate mental health resources in many areas of the country for those with significant mood issues.

The result appears to be a fairly significant disconnect between what healthcare professionals are discussing with their patients and what their patients want to hear. In the current healthcare environment, the primary focus during short neurology visits tends to be on disease-modifying therapies, with the result that little time is available to talk about wellness strategies. However, as people develop their MS-management plan, they want to understand the role of wellness behaviors, such as dietary modifications, exercise, stress management, and mindfulness, as well as the role of conventional medicine, including disease-modifying therapies and symptom-management medications and strategies. They are asking whether both conventional medicine and wellness behaviors are necessary, whether wellness strategies could be used instead of medication(s), how the greatest benefits be gained, and how soon.

Addressing the Communication Gaps
To address these priorities, the Society convened a group of people with MS, healthcare professionals, researchers, and Society staff in November 2014 to take the following steps: • Review the current knowledge in the areas of diet, exercise, and emotional wellness. • Identify gaps in knowledge in these areas to inform the Society’s research agenda. • Suggest educational resources and support programs in these areas to better meet the needs and interests of people living with MS. This article reflects the experiences, opinions, and consensus recommendations of the individuals who participated in this meeting.

Achieving Wellness
The effort to achieve wellness is a lifelong, holistic process that occurs across multiple dimensions—physical, emotional, social, intellectual, occupational, and spiritual—each of which exists along a continuum.2 A person’s pursuit of wellness involves taking action and making lifestyle choices in some or all of these dimensions with the goal of attaining optimal well-being. While the lifelong process is unique for each individual, wellness is attainable for everyone within the context of his or her priorities and abilities—with a starting point being effective communication between the patient and his or her healthcare providers. That being said, other matters beyond the communication gaps addressed in this article have been shown to reduce utilization of health promotional and wellness services among adults with MS, including educational, social, economic, and disease-related factors that also need to be taken into account in our efforts to help people achieve their optimal wellness.3

Wellness—What do we know? What questions remain to be answered?
An online search for information about diet, exercise, and mood in MS yielded nearly 50 million hits. The challenge for both patients and clinicians lies in trying to make sense out of the array of facts, opinions, advertisements, and personal experiences. Even within the scientific literature, the information is inconclusive and sometimes contradictory.

The following studies suggest that diet may play an important role in determining the risk for MS and of disease progression: • Research findings point to obesity as a possible risk factor for developing MS. The incidence of MS appears to be increasing worldwide4 at the same time that caloric intake and being overweight or obese are.5 In recent studies, obesity and body size at age 18–20 were associated with an increased risk for MS6 as was higher body mass index (BMI) at age 7–13.7 (As defined by the World Health Organization, obesity is defined as a body mass index [BMI: weight in kilograms divided by the square of height in meters—kg/m2] equal to or greater than 30.) Obesity is also associated with low-circulating 25-hydroxyvitamin D concentrations,8 which, in turn, are related to disease activity in MS.9 • Recent evidence points to sodium intake as a potential factor in MS disease activity. Sodium is a primary component of salt. In an observational study, people who consumed a moderate or high amount of sodium had a higher rate of relapses and a greater risk for developing a new lesion on magnetic resonance imaging than people who consumed a low amount of sodium.10 • Several studies have suggested a role for low levels of vitamin D in disease onset11,12 and disease progression.13,14 Vitamin D supplementation is being evaluated in a randomized, controlled clinical trial to determine whether this apparent relationship is real or coincidental, and whether the potential benefits outweigh any risks for people with MS. • The potential role of polyunsaturated fatty acids (PUFAs) in slowing disease activity has also been studied, with mixed results. In a Cochrane Review,15 PUFAs did not affect disease progression although relapses seemed to be less frequent. As is being performed with vitamin D supplementation, carefully controlled trials are necessary to identify potential benefits and risks. • The gut microbiota, which is influenced by diet and other factors, modulates the immune system and appears to play a role in MS onset.16,17 • Chronic caloric restriction attenuates experimental autoimmune encephalomyelitis18 and intermittent feeding attenuates clinical course of experimental autoimmune encephalomyelitis in C57BL/6 mice.19 Overall, research studies in the area of diet have generally been of inadequate size and design to provide conclusive information about dietary strategies in MS. For example, in the Cochrane review on dietary interventions,15 only six randomized, controlled trials of PUFAs (with a total of 794 patients) met the inclusion criteria for the review. The evidence available thus far related to dietary factors is insufficient to establish either efficacy (how well a particular diet or supplement works in the structured environment of a controlled clinical trial) or effectiveness (how consistently or persistently people can use a diet or supplement in everyday life).

The following questions need to be answered about diet in MS: 1. What is the impact of a given dietary strategy on the underlying disease process in MS? On symptoms? 2. Are different dietary strategies effective for different individuals, or does one type of diet fit all people with MS? 3. Is it possible for people to change their eating habits over the long term? 4. How can researchers identify those dietary interventions that might hold promise for people with MS? 5. Do dietary interventions change the way MS medications are absorbed and used by the body?

A substantial body of research demonstrates that exercise is good for a person’s overall health and for reducing comorbidities, including obesity, cardiovascular disease, some cancers, type 2 diabetes, osteoporosis, and mood disorders.20 In people with MS, exercise has been shown to be effective for improving aerobic capacity21–23 and muscle strength,24,25 mobility,26,27 quality of life,28 and symptoms of fatigue.29 Exercise may also be effective in treating depression, although the evidence is conflicting.30–33 In spite of all the purported benefits of exercise for people with MS, the efficacy or effectiveness of any specific exercise program for people with MS has not been established.34

Of note, the amount of sedentary behavior among people with MS is alarmingly high, regardless of their physical abilities or limitations35; yet we know very little about strategies that help people become more physically active. Klaren et al.36 report data from a pilot trial suggesting that a behavioral intervention can reduce sitting time in people with MS, but conclude that more research is needed to determine the impact of reduced sitting on function, symptoms, quality of life, and health status.

The following questions need to be answered about exercise in MS:
1. Is exercise training a disease-modifying and/or symptomatic therapy? Does exercise influence the underlying disease process in MS?
2. What is the effect of exercise on symptoms, including cognition, sleep, and pain? Does exercise help manage more severe symptoms as well as milder symptoms?
3. What is the optimal amount (intensity and frequency) of exercise for people with MS? Does the optimal amount vary by severity of the disease?
4. How do we encourage and support the initiation and maintenance of exercise behaviors in people with MS? What is the role of healthcare professionals in encouraging people with MS to exercise?
5. What are the causes of sedentary behavior among people with MS? Can increasing a person’s overall activity level produce benefits similar to those seen with a regular exercise program?
6. How do individuals with MS differ (in terms of disease course, disease severity, symptoms) in the kinds of exercise that would be most beneficial?

Emotional Wellness
From the time of diagnosis, people with MS use a variety of selfmanagement strategies to maintain or enhance their emotional wellbeing in the face of MS-related challenges. However, due to a variety of factors (small study sizes; inadequate design of clinical trials; and a lack of consistency in the groups studied and in the way anxiety, depression, or stress is defined and measured), research has not determined the efficacy or effectiveness of most of these interventions. Thus far, research suggests that:

• Exercise (aerobic and, perhaps, resistance training) may help reduce depressive symptoms and being physically active may help people feel less depressed over time;30,31
• Telephone-delivered physical activity counseling (including motivational strategies, goal-setting, and action planning) may reduce the severity of depression in people who become more active;37
• Acupuncture, Feldenkrais, guided imagery, hypnotherapy, massage, meditation, mindfulness, music therapy, prayer and spirituality, Tai chi, and yoga may be effective in reducing mild to moderate depressive symptoms, anxiety, and stress;38
• St John’s wort may be effective for treating mild to moderate depression in some individuals;39
• Adaptive and solution-focused coping help to promote adaptation and adjustment in MS;40,41 and
• Stress-management strategies of various types may help to reduce stress and improve mood and quality of life.38,42,43

People with MS who experience more severe mood disturbances, including major depression, may be unable to engage actively or effectively in any wellness strategies, including emotional wellness strategies, physical exercise, or healthy eating practices. For these individuals, identifying and treating the mood disturbances is necessary before they can embrace lifestyle changes that may lead to wellness.

The following questions need to be answered about emotional well-being in people with MS:

1. Can we demonstrate in controlled clinical trials the impact of wellness behaviors, such as guided imagery, prayer and spirituality, and massage, on feelings of depression, anxiety, and stress?
2. Can we identify a “menu” of effective strategies (including medication, psychotherapy, and wellness behaviors) that could be tailored to the emotional needs of each individual at different points in time?
3. How do we attract, train, and retain mental health professionals in MS care?
4. How can we ensure that people at risk for significant mood disturbances are identified at different points in the disease course?
5. Who, in addition to mental health professionals, can safely and effectively treat mild to moderate mood issues?

Wellness Research—Challenges to Addressing Gaps in Our Knowledge
The review of the published research about diet, exercise, and emotional wellness highlighted the importance of determining the relative efficacy and effectiveness (see “Addressing the Communication Gaps”) of wellness strategies—alone or in combination—for managing symptoms, reducing other (comorbid) health conditions, and enhancing the impact of diseasemodifying therapies on MS disease activity.

Several challenges must be overcome to address these gaps in knowledge and establish a successful research agenda:

• How to identify and prioritize the target groups to study, for example:
– Individuals with relapsing disease or those with progressive disease.
– Individuals who are newly diagnosed, for studies designed to prevent
symptoms or progression, or those with more progressed MS for studies designed to intervene and provide disease modification or symptom relief. • How to determine the appropriate control group for each study to demonstrate most clearly the impact of the intervention being studied, for example:

– A group on the waiting list for the intervention.
– A group receiving a sham intervention (placebo) or a different treatment intervention (known as an “active control”).
– A group receiving standard care.

• How to address the challenges in adhering to a wellness intervention (e.g., a diet, exercise regimen, or mindfulness protocol) over long periods of time.
• How to address the ways in which significant mood changes and/or MS-related cognitive changes may influence a person’s ability to engage in wellness activities, such as exercising and eating a healthy diet.
• How to find and train knowledgeable scientific reviewers to assess wellness research proposals that are somewhat different from proposals submitted for basic science (laboratory) research.
• How to address concerns some in the medical community may have that wellness research is not a high priority.
• How to expand resources to fund large-scale, well-designed, and controlled multisite studies in wellness.

Wellness Research Recommendations
After careful consideration of the identified research gaps and challenges, the following recommendations were made:

1. Engage research design experts to address the challenges identified within and across wellness areas.
2. Stimulate collaborative research efforts, similar to what has been carried in the areas of genetics, nervous system repair, and progressive MS, to ensure that the best minds are working with speed and effectiveness in wellness research.
3. Identify funding partners who share our interest in increasing knowledge about wellness interventions in MS.

In the Meantime—Recommendations for Clinician–Patient Interactions
In each of the targeted wellness areas—diet, exercise, and emotional health—strategies were identified to expand education and resources for people with MS and healthcare providers to promote physical and emotional well-being.

• Provide clear recommendations to people with MS based on what is known today about the role of diet in overall health:

– Limit sugar and processed foods (particularly those high in sugar, salt, and sodium).
– Increase fruits and vegetables.
– Choose lean sources of protein.
– Choose healthy fats.
– Consume adequate fiber and fluids.

• Provide unbiased information about popular “MS diets” to support educated decision-making (see Table 1).
• Focus on reducing obesity since it appears to increase the risk for MS, and also increases the risk for other health conditions that can worsen a person’s MS.
• Consider creating dietary guidelines for people with MS.

• Provide clear recommendations based on what we know today about the impact of exercise on overall health, MS symptoms (including mobility, weakness, balance, cognition, mood, and pain), and quality of life.
• Educate healthcare professionals about the role of exercise in health and MS management, and encourage them to talk to their patients about “exercise as medicine.”
• Partner with community organizations (e.g., the YMCA) to provide exercise programs for people with MS.

Emotional Wellness
• Develop strategies and tools to increase doctor–patient conversations about emotional wellness beginning at the time of diagnosis, such as:

– Toolkit of information tips and tools for people with MS to identify mood changes in themselves and talk about those changes with their healthcare provider(s); and
– Information and tools for healthcare professionals to talk about mood changes with their patients and to facilitate referrals to the Society and mental health professionals in the community.

• Identify proactive strategies to promote emotional well-being and prevent significant mood disruption in people newly diagnosed with MS.
• Increase the numbers of individuals (peers with MS, Society MS Navigators, mental health professionals) who can deliver effective interventions (prevention, diagnosis, treatment, support) from the time of diagnosis onward.

The Society’s Response
Based on the recommendations from this meeting, the Society has convened a work group in June 2015 to address the following concerns about depression in MS:

• Lack of well-designed studies to identify the cause(s) of mood changes and the interventions that might be helpful for each individual.
• High prevalence of severe depression and anxiety among people living with MS.
• Underdiagnosis and undertreatment of depression and other mood changes in people with MS.
• Complex, probably interrelated, causes (immune changes and changes in the brain, as well as psychosocial stressors) of depression in MS.
• Impact of depression on quality of life, ability to take care of oneself, adherence to treatment, and MS symptoms, such as cognition, pain, and fatigue.
• Possible role of depression and stress in central nervous system inflammation and the disease process.
• Insufficient numbers of mental health professionals to provide diagnosis and treatment.

In addition, the Society will:

• Design and implement a strategy to educate healthcare professionals about the role of wellness in MS comprehensive care and the importance of diet, exercise, and emotional wellness;
• Create an MS Wellness Research Network—including researchers in the areas of diet, exercise, and mood, as well as researchers from other disease groups and experts in study design and statistical analysis— with the goal of developing study design criteria and specific research methodologies for wellness-focused research;
• Develop a long-term strategy for funding research in wellness interventions; and
• Evaluate existing programs and explore development of new programs that would inform, encourage, and facilitate participants’ pursuit of personal wellness.

People living with MS identify wellness as a high priority in their lives. They want to know what they can do today—particularly related to diet, exercise, and emotional wellness—to feel and function at their best. In addition, they want the support of knowledgeable healthcare professionals, who are armed with accurate information about wellness interventions, as they pursue their wellness goals. At a recent meeting convened by the Society, people with MS, healthcare professionals, researchers, and Society staff summarized what is currently known about diet, exercise, and emotional issues in MS; identified key questions to be answered in each of these areas, along with the research gaps and challenges to be addressed to arrive at the answers; made specific programmatic recommendations to ensure that people living with MS are getting the personalized support and information they need to achieve wellness; and outlined next steps to move this important priority forward.

Article Information:

Pavan Bhargava, MD, receives funding from the National Multiple Sclerosis Society through a Sylvia Lawry Physician Fellowship Award. Maura Dunn, MS, and
Rosalind Kalb, PhD, have no conflicts of interest to declare. No funding was received for the publication of this article.


Rosalind Kalb, PhD, 290 Sabino Road, West Bath, ME 04530, US. E:


This article is published under the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, adaptation, and
reproduction provided the original author(s) and source are given appropriate credit.


The authors wish to acknowledge Wellness Meeting steering committee members, Barbara Appelbaum, ACC, MBA, MAT, Barbara Giesser, MD, and Patricia Kennedy, RN, CNP, MSCN, and the work of Dawn Ehde, PhD, Robert Motl, PhD, and Ellen Mowry, MD, who provided literature review and moderated discussions around gaps, challenges, and opportunities in the areas of mood, exercise, and diet for this meeting.




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